Vascular dementia is a neurodegenerative disease. This disease is also known as vascular contributions to cognitive impairment and dementia (VCID). As well documented, VCID has high morbidity and mortality, and diabetes is a leading factor in the development of VCID. However, the [....] » Read More
The NICE guidelines in November 2006 stated: "People with mild / moderate dementia of all types should be given the opportunity to participate in a structured group cognitive stimulation programme. This should be commissioned and provided by a range of health and social [....] » Read More
Biomarkers enable pre-early diagnosis, guide targeted therapy and monitor the active ty and therapeutic responses across the diseases. Among the best-validated predictive biomarkers are autoimmunity-related ones to predict and prognosticate risks of the chronification, complicati [....] » Read More
Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundreds of FDA approved medical products. While nanomedicine has been around for several decades, new technological advances are pushing its boundaries. For exa [....] » Read More
Currently, the major focus of research on tumor immunity is the adaptive immune system involving T- cell activation/targeting of human cancers; however, the innate immune system represents a critical first-responder line of defense coordinating in situ anti-cancer responses with [....] » Read More
The dopamine measurement in human blood or urine could be an valuable index in the neuropsychiatric disorders. Dopamine belongs to a class of analytes for biosensors, known as neurotransmitters from the catecholamine family. Neurotransmitters have implications in brain functions, [....] » Read More
Research increasingly supports the concept that cognition should be considered the 5th Vital Sign, highlighting the critical importance for neurological practices to measure cognitive functioning routinely. Early diagnosis of cognitive disorders and cognitive dysfunctions is a ma [....] » Read More
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). To achieve the implementation of PPM concept, it is necessary to create a fundamentally new strategy based upon the recogni [....] » Read More
Brain-computer interface (BCI) is a research field that involves analyzing and classifying signals from brain activity using machine learning or deep learning and applying them to various applications. Speech imagery decoding involves analyzing brain waves induced by the user&rsq [....] » Read More
Introduction: Previous studies have suggested that therapeutic treatments aimed at preserving neuromuscular junction (NMJ) may play an imperative role in fighting against amyotrophic lateral sclerosis (ALS). However, as far as repetitive nerve stimulation (RNS) test, a technique [....] » Read More
Objectives: Aim of this study was to investigate association between neurological with manifestations and antiphospholipid antibodies type and level in APS patients. Methods: Our prospective study comprises of 333 patients: 218 with primary and 115 with secondary APS. Antiphosph [....] » Read More
Psychological disabilities such as Major depressive (MD) and anxiety-like disorders are a leading cause of global economic and social burden. While current treatments offer some effectiveness, they often fall short. This underscores the urgent need for faster-acting and more effi [....] » Read More
Immune checkpoint inhibitors (ICIs) have emerged as a pivotal class of immunotherapy in the treatment of various cancers. These therapies, while highly effective, can also lead to a spectrum of immune-related adverse events (irAEs), one of which is vasculitis affecting the centra [....] » Read More
The disorder of the development of the SN during the embryonic period is at the origin of malformations of cortical development (MDC) which represent a major cause of mental and motor disabilities as well as severe eilepsy. We describe here a syndrome called Kiza-Ntenga syndrome [....] » Read More
Background: Lyme Neuro Borreliosis (LNB) is a tick-borne neurological infection, caused by the spirochetes of the Borrelia burgdorferi sensu latu complex. In Europe, LNB is among the most common bacterial neurological infections. In adults, typical nervous system manifestations i [....] » Read More
Predicting outcomes of postanoxic states, especially concerning motor function control, is a crucial aspect of the rehabilitation process. This series of clinical observations presents the reorganization of cortical motor representations (primary motor cortex, premotor cortex, su [....] » Read More
In India, a considerable portion of the population is affected by mental illnesses due to inadequate coverage of mental health care. Psychiatric disorders pose increasing challenges from both sociological and economic standpoints. Physicians confront difficulties in opt [....] » Read More
With more than 7,000 identified rare diseases and approximately 80 % being linked to genetic causes, diagnosing rare disease patients can often be difficult – resulting in lengthy, expensive, and emotional diagnostic odysseys, but with revolutionary advances in Molecular [....] » Read More
Mutations in PINK1 and PARKIN lead to inherited forms of Parkinson’s Disease (PD). My lab was one of the first to report the function of the PINK1 gene, and to show that PINK1 and parkin function in a common pathway to regulate mitochondrial integrity and quality. Mitoch [....] » Read More
Post-dural puncture headache (PDPH) is an important and relatively frequent complication after spinal anesthesia. It is intense pain that worsens when sitting or standing and improves when lying down. Epidural blood tamponade is the most effective treatment, but it is invasive. - [....] » Read More
Transformers, one of the remarkable machine learning techniques, are widely used not only in the artificial intelligence fields due to their remarkable ability to handle the problem of long-term dependencies. In this study, our objective is to develop an electroencephalogram (EEG [....] » Read More
Ischemic stroke is a leading cause of morbidity and mortality globally. The high interfacing ratio of patients to professionals in Pakistan’s population is a great hindrance to access to care. This study intends to develop a computer-aided detection and classification syste [....] » Read More
Background: With no randomised controlled trials or consensus guidelines for the treatment of anti-NMDAR encephalitis, the heterogeneity in the treatment stratagem has not yet reported any evidence on the therapeutic option of choice when infections ensue during the immunosuppres [....] » Read More
This presentation, titled "Tailored Care homes for Neurological Disorders: A Person-Centered Approach," delves into the critical role of care homes and assisted living facilities in developing and implementing individualized care plans for residents with neurological di [....] » Read More
Whole body vibration (WBV) involves using machines or platforms to transmit periodic pulse/wave energy to the body, causing muscles to contract and relax passively. While scientific evidence on the noxious effects of popular WBV machines is limited, experts generally agree that l [....] » Read More
Objective: To investigate the effect of and Acupuncture on brain plasticity and motor development in children with cerebral palsy. Investigate effect on mechanism of apoptosis of brain nerve cells, regulating the expression of neurotrophic factors, promoting the remodeling of ner [....] » Read More
Gamma-amino butyric acid (GABA) is the main inhibitory neurotransmitter in the brain and GABA-ergic transmission is important for the regulation of learning and memory. The progesterone metabolite allopregnanolone (Allo) is a potent positive GABA-A receptor modulating steroid (GA [....] » Read More
Fortunately the incidence of Traumatic Spinal Cord Injury (TSCI) is rare 10-50/million population/year. Trauma to the spinal cord however results in a multi-system physiological impairment and malfunction, paralysis, sensory loss and a potential wide range of medical and non-medi [....] » Read More
Malignant Glioblastoma Multiforme is the most aggressive of the gliomas, a collection of tumors arising from glia or their precursors within the central nervous system. It accounts for 17% of all primary brain tumors which makes GBM the most common malignant brain tumor. Even wit [....] » Read More
Creutzfeldt Jakob disease (CJD) is a fatal transmissible spongiform encephalopathy (TSE) similar to diseases occurring in animals. Management of these diseases has been a disaster over the past fifty years since there has been total reliance on a flawed theory regarding pathogene [....] » Read More
Background: Guillain Barre syndrome (GBS) is a very well-studied condition in neurology which usually associated with antecedent infections, predominantly gastroenteritis or chest infection over the past few weeks. Among its variants, acute motor and sensory axonal neuropath [....] » Read More
Objectives: To compare the protein coding transcripts differences before and after different induction time of adipose-derived stem cell (ADSC)-induced Schwann-like cells (iSCs). Methods: Isolation of ADSCs from healthy adult female rats was performed. The iSCs of 7 days and 1 [....] » Read More
Currently, most clinical practice and scientific research revolves around a single disease or system, and the single disease-oriented diagnostic and therapeutic paradigm needs to be broken. This review describes how transcutaneous auricular vagus nerve stimulation (taVNS), a nove [....] » Read More
Considerable interest has been, and still is, generated by the potential performance enhancing benefits of EEG biofeedback or Neurofeedback training (NFT). A plausible rationale for such training, with an aim to improve mood and or enhance cognition, can be made based upon what i [....] » Read More
Encephalitis is a frequent cause of neurological consultations for hospitalized patients. However, understanding this syndrome is just one piece of the puzzle. The clinical presentation of encephalitis often shares similarities with infections, parainfections, post infections, an [....] » Read More
Background: Caffeic acid phenethyl ester is found in honey bee propolis. It has immunomodulatory, anti-inflammatory and anti- cancer properties. Rotenone is a pesticide commonly used for inducing experimental Parkinson’s disease (PD) due to complex I inhibition and microgli [....] » Read More
Parkinson's disease (PD) stands out as one of the most prevalent neurodegenerative conditions, typically manifesting in later stages of life, characterized by the gradual deterioration of motor functions. Recently identified environmental factors either increase the risk or d [....] » Read More
This abstract outlines the personal experience of an individual (myself) who is a physician and also a patient diagnosed with MOGAD (anti-MOG positive NMOSD). The diagnostic journey spanned over four years, characterized by a diverse array of symptoms, initially dismissed or attr [....] » Read More
Parkinson's disease (PD), after Alzheimer's, is the second most important age-related neurodegenerative disease whose prevalence and incidence increase almost exponentially with age and reach a peak after the age of 80. PD is primarily characterized by a selective loss of [....] » Read More
Ulnar nerve entrapment across the elbow (UNEAE) and across wrist (UNEAW) is the second most common entrapment of the hand after carpal tunnel syndrome. There are few gradings available for UNEAE and lesser in UNEAW. The aim of this research is to create a clinically appropriate u [....] » Read More
It has been noted by multiple researchers that there is Spontaneous Electrical Activity (SEA) at painful trigger points. This author has studied chronic muscle spasm and found that SEA is always present and appears to be the cause for the chronic nature of muscle spasm and result [....] » Read More
Patients with psychogenic nonepileptic seizures (PNES), also known as Functional Seizures (FS), have involuntary paroxysmal episodes that resemble epileptic seizures but without organic etiology. Patients with PNES are frequently misdiagnosed and mistreated for epileptic seizures [....] » Read More
The grading systems proposed by Bland and Padua are the most commonly used are very old and and both have limitations. The aim of this research is to establish, using the best available evidence, a clinically appropriate revision of the current CTS nerve conduction grading tool, [....] » Read More
Neurons are the fundamental units of the brain and the nervous system. The variable structure model of neurons is a system of differential equations with various parameters. By optimizing these parameters, we can create a unique model that describes the dynamic behavior of a sing [....] » Read More
Injury and disease can lead to a myriad of neural control problems (e.g., following spinal cord injury or stroke). Rehabilitation is a leading therapy for patients, but it only leads to modest neural plasticity & recovery. Targeted plasticity therapy (TPT) is an emerging ther [....] » Read More
Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons and the presence of intracellular inclusions, named Lewy bodies that are mainly composed of misfolded proteins. The accumulation of misfolded proteins is a molecu [....] » Read More
Glioblastoma (GBM), grade IV glioma, is the most prevalent/malignant primary brain tumor in adults. The therapeutic benefit from standard treatment remains limited and median survival of GBM patients is around 15 months. Glioblastoma stem cell-like cells (GSCs) are a su [....] » Read More
The present review aimed to establish an understanding of the pathophysiology of leptomeningeal disease as it relates to late-stage development among different cancer types. For our purposes, the focused metastatic malignancies include breast cancer, lung cancer, melanoma, primar [....] » Read More
Background: Obstructive sleep apnea syndrome (OSAS) and atrial fibrillation (AF) has been previously linked to elevated risk of ischemic strokes. However, the additive impact of both OSAS and AF on the long-term outcomes of patients with ischemic stroke remains largely unknown. [....] » Read More
Background: On the basis of conventional treatment, explore the clinical efficacy of acupuncture calming the mind on the functional impact of patients with post-stroke depression (PSD). Methods: Select hospitalized PSD patients treated in our hospital from January 2019 to Dece [....] » Read More
Objective: This review aims to explore the effects of personalized care and early rehabilitation on patients with intracerebral hemorrhage and how these approaches improve patient survival rates and functional outcomes. Methods and Materials: The literature review primarily reli [....] » Read More
Introduction: Anti-calcitonin gene-related peptide (CGRP) migraine medications may also reduce symptoms of depression, a comorbid disease of migraine with overlapping genetic background. Currently, we do not understand the biological background of this phenomenon. Here, we a [....] » Read More
The approach to hyponatremia is in a state of flux, especially in differentiating Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH) from cerebral-Renal Salt Wasting (RSW) because of diametrically opposite therapeutic goals of water-restricting in SIADH and admin [....] » Read More
Background: Multiple sclerosis (MS) is an abnormal immune-mediated response that results in damage within the central nervous system causing physical limitations, cognitive changes, and psychological distress. With the advent of disease-modifying therapy (DMT), patients can exper [....] » Read More
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Title : Effects of neuronavigated TPS: A novel tool of Non Invasive Brain Stimulation (NIBS)
Ulrich Sprick, Heinrich Heine University, Germany
Treatments of patients with severe therapy-resistant dementia and depressive disorders repeatedly pose enormous challenges in psychiatry and neurology. Transcranial pulse stimulation (TPS) as a new non-invasive therapy method could represent a new alternative to standard treatmen [....] » Read More
Title : Neuroinflamation and venous lesion of the neck veins role in inner ear disease
Aldo Bruno, Vascular Dep PIO XI Clinic Rome, Italy
Purpose: To evaluate the relationship between Meniere’s disease and chronic cerebrospinal venous insufficiency (CCSVI) using ultrasonography, magnetic resonance imaging, and venography and the effectiveness of angioplasty for reducing the symptoms of inner e [....] » Read More
Title : Development of the early diagnosis of parkinson’s disease at the prodromal stage
Michael Ugrumov, Institute of Developmental Biology RAS, Russian Federation
Parkinson’s disease (PD) is diagnosed many years after its onset, under a significant degradation of the nigrostriatal dopaminergic system, responsible for the regulation of motor function. This explains rather low effectiveness of the treatment of patients. Therefore, one [....] » Read More
Title : Synaptic plasticity induced by transcranial magnetic stimulation
Joshua Brown, Harvard Medical School, United States
Transcranial Magnetic Stimulation (TMS) now has widespread clinical utility far outpacing an understanding of how it modulates the brain – limiting optimization. Behavioral and network effects are subserved by cellular changes, most prominently at the synapse. ‘Excita [....] » Read More
Title : Genetic and cytokine influences on cognitive recovery following traumatic brain injury: A longitudinal study
Emily R Rosario, Casa Colina Hospital and Centers for Healthcare, United States
Objectives: This study aimed to investigate the relationship between APOE genotype, cytokine levels, and cognitive outcomes in patients recovering from traumatic brain injury (TBI). The objectives were to assess the impact of APOE ε2 and ε4 variants on cytoki [....] » Read More
Title : Brain health update: Current trends and future directions
Dixie J Woolston, Mayo Clinic Arizona/Scottsdale, United States
The field of brain health is undergoing rapid advancements, driven by increasing understanding of the brain's complexity and the rising prevalence of neurological disorders. This update explores current trends and future directions in brain health research and practice. Recen [....] » Read More
Title : The brain mechanism regulating mammalian reproduction
Hiroko Tsukamura, Nagoya University, Japan
Accumulating evidence suggests that hypothalamic kisspeptin neurons are the master regulator for mammalian reproduction to govern the hypothalamus-pituitary-gonadal (HPG) axis. Indeed, mutation or deletion of kisspeptin gene (Kiss1) or its receptor gene (GPR54) causes hypog [....] » Read More
Title : Recent advances in brain imaging
Mohit Saxena, Northwestern University Feinberg School of Medicine, United States
Introduction: Brain surgery may benefit from functional MRI (fMRI) that can detect changes in cerebral blood flow and oxygen utilization caused by tissue activation. Therefore, the patient needs to perform certain tasks in the scanner while fMRI is acquired. However, task-ba [....] » Read More
Title : EEG application pre-and post-cerebral cortex disconnection surgery in intractable epilepsy
Shuhua Chen, Capital Medical University, China
Cerebral cortex disconnection surgery is a surgical treatment method for drug-resistant epilepsy patients. By this surgical technique,the connection between the epileptic cerebral tissue and its related structures and adjacent brain tissue were disconnected completely. It means t [....] » Read More
Title : In vitro investigation of neuroprotective effects: Unveiling the impact of Aβ25-35-induced oxidative stress on SH-SY5Y cells and the therapeutic potential of phytochemicals
Harkomal Verma, Central University of Punjab, India
Alzheimer’s disease (AD) is intricately linked to oxidative stress induced by the accumulation of amyloid beta (Aβ) peptide, disrupting cellular functionality. This comprehensive study investigates the multifaceted impacts of Aβ25-35-induced oxidative stress on hu [....] » Read More
Title : Understanding academic and educational problems fit for purpose in the contributing to attentional and learning difficulties in our children
Rahul Hajare, Sandip University, India
Innocent smile is a natural transition that consists of biological and psychological changes that occur for children. ADHD, painful, is a common condition of pain that affects a wide range of young children capable of reducing their quality of life, decrease their ability to func [....] » Read More
Title : Exploring the enablers and barriers to implementing evidence-based practice in acute stroke care
Kelsey Bonnici, University of Malta, Malta
The integration of evidence-based practises (EBPs) plays a crucial role in enhancing patient outcomes and lessening the impact of post-stroke disability, particularly in the realm of acute stroke care within the healthcare field. The objective of this study is to explore the vari [....] » Read More
Title : Validation of instadx, a clinical decision support tool information technology based application for ischemic stroke sub-type diagnosis
Saadia Sattar, Aga Khan University, Pakistan
Globally ischemic stroke is the second leading cause of mortality and morbidity among the adult population. Prompt diagnosis of ischemic stroke sub-type can lead to better clinical outcomes. This study aimed to adapt and develop mHealth-based android application ‘InstaDx&rs [....] » Read More
Title : Role of care homes & assisted living facilities in caring for people with neurological disorders
Veronicah Akankunda, Golden Age Elderly Homes Kampala, Uganda
Introduction: Dementia is an age mental disorder that makes victims lose normal functionality that need delicate attention. It has been technically defined as a clinical syndrome characterised by a cluster of symptoms manifested by difficulties in memory, disturbances in spe [....] » Read More
Title : Transcranial pulse stimulation for the treatment of patients with alzheimer's dementia
Dilana Hazer Rau, Storz Medical AG, Switzerland
Transcranial Pulse Stimulation (TPS) is a non-invasive procedure for the treatment of patients with Alzheimer's disease. Alzheimer is the most current form of dementia, affecting millions of patients worldwide. As a neurodegenerative disease, it is associated with a prog [....] » Read More
Title : Clinical improvement of visual complaints in benson’s symdrome with TPS-treatment: A case series on atypical dementia
Ali Riza Gunes, Alexius/Josef Hospital Neuss, Germany
Background: Atypical dementias often go unrecognized in everyday clinical practice. In 1988, Frank Benson and colleagues first described a case series of 5 patients with progressive visual complaints in the form of Balint's syndrome (visual ataxia, ocular apraxia, simult [....] » Read More
Title : TPS vs TMS - A power comparison
Oliver Seemann, Psychiatriezentrum Breitenau, Switzerland
rTMS (repetitive transcranial magnetic stimulation) is yet a well know neurostimulation technique, which is now challenged by TPS (transcranial pulse stimulation). TMS has been investigated since around 40 years and conquered an undisputed place in clinical treatment, most of all [....] » Read More