Ljudmila Stojanovich

Title : A wide variety of neurologic manifestations in the antiphospholipid syndrome

Abstract:

Objectives: Aim of this study was to investigate association between neurological with manifestations and antiphospholipid antibodies type and level in APS patients.
Methods: Our prospective study comprises of 333 patients: 218 with primary and 115 with secondary APS. Antiphospholipid antibody (aPL) analysis included detection of aCL(IgG/IgM), ß₂GPI(IgG/IgM) and LA and served to evaluate correlations with distinct neurological manifestations.
Results: Presence of aCL IgG was more common (p=0.001) in SAPS patients and LA in PAPS patients (p=0.002). According to gender, males more likely develop stoke (p=0.026) and multiinfarct dementia (p=0.004) in SAPS then females.  High ß₂GPI IgM levels (>100PLU/ml) were more common in epilepsy (p=0.00001) in PAPS, and in transient ischemic attack (p=0.029) in SAPS. High ß₂GPI IgG levels (>100PLU/ml) were more common in stroke (p=0.036) and epilepsy (p=0.035) in SAPS. Almost significant was correlation between the presence of high and medium levels aCL IgM and migraine (p=0.053) in PAPS. Chorea, migraine and epilepsy occurred more often in SAPS and cerebral venous sinus thrombosis, cephalea and depression in PAPS. We revealed statistical significance considering the presence of aCL IgG and accute ischemic encephalopathy in SAPS, aCL IgM and epilepsy in SAPS, aCL IgM and migraine in PAPS, ß₂GPI IgG and stroke and chorea in SAPS and ß₂GPI IgM and TIA and epilepsy in PAPS. LA correlated with depression, transient global amnesia and migraine in PAPS.
Conclusion: Our study showed that certain aPL type and levels correlated with distinct neurological manifestation, suggesting their predictive role.

Biography:

Ljudmila Stojanovich received her Ph.D. in Medicine in 1999. She is the scientific director in the Bezhanijska Kosa, University Medical Center of Belgrade University. She is an author of three monographs and of about 250 articles on various aspects of Autoimmune Rheumatic disorders. She is in Editorial Boards (LUPUS /LONDON). She is a member of number International Project,  and member of the Steering Committee of the “EULAR recommendations for the prevention and management of adult antiphospholipid syndrome". Professor Stojanovich is EULAR Honorary Member, and the President of “12^th meeting of the European Forum on APS”, in Belgrade, Serbia in Marth 2021.