Vascular contributions to cognitive impairment and dementia (VCID) is a common neurodegenerative disease. This dementia includes all types of vascular dementia. It is caused by brain cerebral blood vessel dysfunctions. VCID has high morbidity and mortality. Diabetes is a leading [....] » Read More
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, Personalized and Precision Medicine (PPM). PPM is an emerging approach to healthcare that aims to optimize medical treatment by tailoring it to the specific character [....] » Read More
Parkinson’s disease (PD) is the second most common neurodegenerative disorders. Mutations in PINK1 and PARKIN lead to inherited forms of PD. My lab was one of the first in the world to report the function of the PINK1 gene, and to show that PINK1 and parkin function in a co [....] » Read More
Many neuroinflammatory diseases are accompanied by neurodegeneration and memory deficits. In a substantial number of these diseases, deleterious causes originating in vasculature play a significant role in the development and/or progression of morbidity. Traumatic brain injury (T [....] » Read More
Introdution: Fibromyalgia is a chronic and heterogeneous condition, characterized by diffuse musculoskeletal pain and associated changes, such as anxiety disorder, sleep disorder, depression, cognitive impairment and fatigue {1}. Fibromyalgia is a frequent cause of pain and [....] » Read More
The 2022 world Alzheimer’s report pointed out the importance of early detection and diagnosis of Alzheimer’s disease (AD), as nearly 75% of individuals with dementia are not diagnosed globally. The histopathological hallmarks of AD are the extracellular amyloid-β [....] » Read More
Growing evidence suggests a link between systemic inflammation and cognitive decline. Studies in cognitively healthy individuals have demonstrated an association between low-grade systemic inflammation, and accelerated cognitive decline. Furthermore, some research indicates a pot [....] » Read More
Among the best-validated predictive biomarkers are autoimmunity-related ones to predict and prognosticate risks of the chronification, complications and thus disabling. The latter is so much valuable and important since chronic autoimmune inflammation course is structured to cons [....] » Read More
Transcranial photobiomodulation (t-PBM) is a novel, non-invasive, neuromodulation technique. It has a wide range of indications in neurodegenerative diseases including mild cognitive impairment (MCI), which serves as a potential preclinical stage of early Alzheimer’s diseas [....] » Read More
Belarusian researchers have developed an algorithm for the clinical and laboratory diagnosis of dementia of various origins, based on the use of clinical indicators and laboratory studies of the concentration of biomarkers of the neurodegenerative process in the blood: β-amy [....] » Read More
Ng the children’s sex and age and the children’s parents’ age and education level, when a diagnosis was determined. We also studied clinical features, including the child’s age at the time of early alert signs and at diagnosis, the core alert sign and symp [....] » Read More
Background: Recent research on Alzheimer’s disease (AD) has highlighted that the oxidative damage is the earliest event of disease. These oxidative modifications are closely associated with inflammatory molecules. It is necessary to explore these two pathways with AD pathop [....] » Read More
Depression, a prevalent condition, has reached unprecedented levels in certain countries, such as Germany, as indicated by the most recent data. Depending on the severity of the condition and the patient's individual preferences, different treatment options are available. How [....] » Read More
A natural nutrition plan for elderly people with neurological disorders should focus on whole, nutrient-dense foods that support brain health and address specific needs. unprocessed foods that promote overall health and address age-related concerns. Remember to consult with [....] » Read More
Nutritional benefits: Quail eggs are rich in: Choline: Essential for brain health, cognitive function, and memory. Vitamin B12: Crucial for nerve function, brain health, and red blood cell formation. Omega-3 fatty acids: Anti-inflammatory effects, supporting brain healt [....] » Read More
The way we perceive our world directly influences our responses to it. There is significant variability in how individuals perceive and subjectively evaluate their environment, even among people experiencing the same conditions. In a healthy human system, perception and response [....] » Read More
Objective: To investigate the effect of and Acupuncture on brain plasticity and motor development in children with cerebral palsy. Investigate effect on mechanism of apoptosis of brain nerve cells, regulating the expression of neurotrophic factors, promoting the remodeling o [....] » Read More
The incidence of Traumatic spinal cord injuries (TSCI) is small and ranges between 10-50/million population/year. Prior to the second WW the great majority of patients died within two years of injury. Since the 2nd WW, due to the efforts of the pioneers who dedicated their profes [....] » Read More
Gamma-Amino Butyric Acid (GABA) is the main inhibitory neurotransmitter in the brain and GABA-ergic transmission is important for the regulation of learning and memory. The progesterone metabolite allopregnanolone (Allo) is a potent positive allosteric GABA-A Receptor Modulating [....] » Read More
The presentation starts by addressing the fields of neurobiology, especially concentrating on the future of neurobiology and the future, connectivity and connectomics. The discussion will also include genetics and neurobiology. Artificial Intelligence and Machine Learning will be [....] » Read More
In 1906, the Italian biologist and pathologist Camillo Golgi and the Spanish pathologist and histologist Santiago Ramón y Cajal shared the Nobel Prize for Medicine and Physiology ‘in recognition of their work on the structure of the nervous system’. They are co [....] » Read More
In the last decade, a radically different scientific concept of developing Life on Earth - as BioRECURSION, or NeuroBLACKCHAIN - has emerged. From the point of view Life is Evolutional formation of Closed-Loop Coding-Decoding (CL-CD) chem-matter biochem procedure that appeared ~8 [....] » Read More
As the world’s population ages, Cognitive Frailty (CF) is becoming one of the most serious health problems and elucidating its biological mechanisms along with prevention and treatments becomes increasingly important also considering the associated health costs. We thus per [....] » Read More
Patients with psychogenic nonepileptic seizures (PNES), also known as Functional Seizures (FS), have involuntary paroxysmal episodes that resemble epileptic seizures but without organic etiology. Patients with PNES are frequently misdiagnosed and mistreated for epileptic seizures [....] » Read More
Nonsurgical treatments, such as nerve block, in chronic pain patients with severe adhesions are reported to have a relatively low effect and a high risk for relapse. This may be attributed to the fact that epidural adhesions themselves are difficult to remove through such methods [....] » Read More
Language mediation, ranging from written translation to interpreting, represents one of the most complex cognitive tasks performed by the human brain which involves an intricate interplay of language processing, executive control, and working memory systems. The neural architectu [....] » Read More
Background: Lymphomas are malignant neoplasms of the immune system, originating in lymphoid organs and having the potential to affect the central nervous system. Notably, lymphomas presenting initially as acute myelitis are extremely rare. Most of these cases exhibit symptoms of [....] » Read More
Further research into the genetic code and its physical properties is an important resource for decoding the neurocode and developing strong artificial intelligence. DNA has a hierarchical spiral structure, which still remains outside of the attention of science. Meanwh [....] » Read More
This case report highlights how Stiff Person Syndrome (SPS) can be associated with severe complications, including heterotopic ossification (HO). HO of skeletal muscle has not been described in the pathophysiology of SPS and has been described in only one other case report of SPS [....] » Read More
Ulnar nerve entrapment across the elbow (UNEAE) and across wrist (UNEAW) is the second most common entrapment of the hand after carpal tunnel syndrome. There are few gradings available for UNEAE and lesser in UNEAW. The aim of this research is: To create a clinically appro [....] » Read More
Transcranial magnetic stimulation (TMS) has emerged as a non-invasive neuromodulation technique capable of inducing neuroplasticity, with significant potential in both basic research and clinical applications. This presentation will explore the application of various TMS protocol [....] » Read More
Brain cancer and its treatments bring a unique threat to the patient’s identity and quality of life by challenging their essential identity in significant ways, possibly including impaired cognitive skills, loss of memory, reduced coordination, altered feeling states, and l [....] » Read More
Chronic pain is defined as persistent pain for more than three months, resulting in changes in the functional synaptic network of the brain and its gray matter dimensions, causing hypersensitivity to a nociceptive stimulus and increased excitability of the nodal stress mechanism, [....] » Read More
Anxiety and depression are major causes of disability worldwide, often worsened by chronic stress. Schinus terebinthifolia Raddi (SteLL) has been traditionally used for various medicinal purposes, including treating depression with bark-and-leaf tea or leaf decoction. Previous st [....] » Read More
Background: General studies of neurocognitive processing across the lifespan have demonstrated gradual declines among healthy adults in the domains of memory, problem-solving, executive functioning, and processing speed. However, a number of specific factors have been [....] » Read More
The importance of the adrenergic transport mechanisms comprehension in the synapses is useful in clinics diagnosis and pharmacology. For this aim, the paper proposes a parallel biodevice composed by Adrenaline Bioliquid On Insulator. Between the Source and Drain of the device is [....] » Read More
Background and aims: Creutzfeldt-Jakob disease (CJD) is a rare, fatal neurodegenerative prion disorder often mimicking other neurological conditions including stroke. This case report highlights the diagnostic challenges in a patient with CJD initially presenting with non specifi [....] » Read More
Introduction: Cerebral infarctions (CI) in young people represent a pathology whose incidence is increasing worldwide. The particularity of this young population lies in the diversity of risk factors, as well as in the etiologies incriminated. The main objective of our study was [....] » Read More
Frontal Alzheimer’s disease (fAD) is an atypical AD variant which is difficult to differentiate from and frequently misdiagnosed as behavioural variant frontotemporal dementia (bvFTD). Most recent work has identified two subtypes of fAD: a behavioural subtype (bAD) associat [....] » Read More
Title : ACE-dependent Alzheimer’s Disease (AD)
Sergei M Danilov, University of Illinois, United States
An analysis of 1200+ existing missense ACE mutations revealed that >400 are predicted to be damaging and led us to hypothesize that heterozygous carriers of these loss-of-function (LoF) ACE mutations (which result in low ACE levels) may be at risk for the development of late-o [....] » Read More
Title : Who cares …… for the carers
Jaqueline Tuppen, COGS Club, United Kingdom
The House of Commons Inequalities in Dementia Care Debate 2024 highlighted that in the whole of the UK, the number of people with dementia is estimated at 850,000 and in England, around 540,000 people care for an individual with dementia. These numbers are replicated around [....] » Read More
Title : Traumatic brain injury in 2025
Jonathan Eskenazi, Neurological Institute of Los Angeles, United States
Definition and Types: TBI is an injury to the brain caused by external force, resulting in a range of effects. It can be classified as mild (concussions), moderate, or severe based on symptoms and impact. Causes: Common causes include falls, vehicle accidents, sports injuries, [....] » Read More
Title : Neurophenomenology in retraining musicians with task-specific focal dystonia: Three cases
Sang Hie Lee, University of South Florida, United States
Musicians experience a high rate of playing-related pain and injury due to the rigorous nature of repetitive mind-body training, specifically musculoskeletal disorders (PRMD), performance anxiety (PA), and task-specific neurological disorder (TSND). TSND is the least understood b [....] » Read More
Title : Scientific-technological integration towards the clinical rehabilitation of spinal cord injured individuals
Alberto Cliquet Junior, UNICAMP, Brazil
Individuals with spinal cord injury rarely have access to innovative technology. The work presented here has allowed sensorimotor recovery to paraplegics and tetraplegics, in addition to the production of cutting-edge technology for control of upper and lower limbs. Neuromuscular [....] » Read More
Title : Targeting the endocannabinoid system: A novel approach to the treatment of traumatic brain injury and stroke
Esther Shohami, The Hebrew University of Jerusalem, Israel
Cannabis is one of the most widely used plant drugs in the world and was used for millennia for its medicinal and mind-altering effects. The latter are known to be mediated via the activation of the endocannabinoid (eCB) receptor CB1. Developments in medicinal chemistry of novel [....] » Read More
Title : Interactions between COX-2 and glutamatergic receptors with CB1 as a novel target in mood and cognitive studies
Katarzyna Stachowicz, Polish Academy of Sciences, Poland
Glutamate, the brain’s primary excitatory neurotransmitter, maintains neuronal communication and functional stability. Together with gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter, it establishes a balance essential for cognitive processes, emotiona [....] » Read More
Title : Neuromedin U induces airway goblet cell hypersecretion through eosinophil-derived interleukin-1α in allergic rhinitis
Changqing Zhao, Shanxi Medical University, China
Background: Neuropeptide neuromedin U (NMU) is elevated in allergic rhinitis (AR) and has been linked to eosinophil activation, but its role in goblet cell (GC) secretion during AR remains unclear. This study aimed to investigate whether NMU induces GC hypersecretion. Methods: [....] » Read More
Title : Neuroimmune mechanisms in nasal hyperreactivity: Unraveling the nose-brain axis
Yanjie Wang, Shanxi Medical University, China
Nasal hyperreactivity (NHR), including conditions such as allergic rhinitis, represents a group of common disorders characterized by complex neuroimmune interactions, with underlying mechanisms that are not fully understood. Communication between the nervous and immune systems pl [....] » Read More
Title : Role of alzheimer’s disease presenilin-1 associated protein in mitochondrial apoptosis
Xuemin Xu, The University of Texas Permian Basin, United States
The process of apoptosis, a programmed form of cell death, is a normal occurrence during neurogenesis in the maturation of the central nervous system. However, dysregulated or premature activation of apoptosis can contribute to the pathogenesis of various neurodegenerative disord [....] » Read More
Title : The loss of PINK1 function alters molecular pathways in human fibroblasts
Yingxue Ren, Mayo Clinic, United States
Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Mutations in the PINK1 and PRKN genes have been linked to early-onset PD and are among one of the most frequent causes for inherited, recessive PD. PINK1 and PRKN together eliminate damaged mitoc [....] » Read More
Title : Brain health factors in aging executives: Insights from Mayo Clinic Arizona’s THRIVE pilot study
Dixie J Woolston, Mayo Clinic Arizona/Scottsdale, United States
Background: Brain health is essential for cognitive, emotional, and behavioral functioning throughout life. The WHO's 2022 position paper emphasized the critical role of modifiable factors—such as physical activity, sleep, stress, and substance use—in maintaining [....] » Read More
Title : The absolute beginner. Right-and lefthand process-based measures in handwriting
Carlo Di Brina, Sapienza University of Rome, Italy
Fine motor performance across ages is traditionally assessed through handwriting and drawing, focusing on both the final product and the kinematic aspects of the movement (Blank et al., 2019; Smits-Engelsman et al., 2001; van Drempt et al., 2011). In kinematic analysis, tablet-ba [....] » Read More
Title : Guidelines application for the treatment of TBI in children A multidisciplinary approach
Zhanna Semenova, Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Russian Federation
Introduction: The main aim of management of pediatric Severe Brain Injury (TBI) is to hold normal ranges for optimizing the most favorable outcomes.Clinical and research Institute of Emergency Pediatric Surgery and Trauma. Annually, more than 10000 children with head injury are c [....] » Read More
Title : Improvement of brain function by wasabi component “hexaraphane”
Isao Okunishi, Kinjirushi Co Ltd, Japan
Hexaraphane (6-methylsulfinylhexyl isothiocyanate; 6-MSITC) is an isothiocyanate present in the rhizomes and roots of Wasabi (Eutrema japonicum (Miq.) Kiudz.). Here we present the results of two clinical trials conducted on healthy subjects and patients with chronic fatigue syndr [....] » Read More
Title : Impact of egg-derived proteins, yolkin polypeptide complex and ovocystatin, on blood-brain barrier integrity and function
Bartlomiej Stanczykiewicz, Wroclaw Medical University, Poland
Introduction: The blood-brain barrier (BBB) is a highly selective and protective membrane that separates the brain from the circulating blood, effectively shielding it from harmful substances, toxins and pathogens. Its primary function is to maintain brain homeostasis, regul [....] » Read More
Title : Phosphorylation of Kv7.2 potassium channel’s regulatory domain alters binding interactions with calmodulin
Sinchana Basoor, UT Health San Antonio, United States
Kv7 channels are potassium ion channels expressed in the nervous system. Kv7 channels function to control the excitability of neurons by reducing the rate of action potential firing. The Kv7.2 channel has been shown to play a particularly crucial role in neurodevelopment. Five di [....] » Read More
Title : Deepthickness: A novel deep learning method for estimating cortical thickness trajectories in healthy and alzheimer’s disease populations
Connor Dalby, University of Glasgow, United Kingdom
Alzheimer's disease (AD) is a neurodegenerative disease that presents with critical challenges in diagnosis and treatment. Emerging research indicates that AD-related cortical changes, such as cortical thickness, can appear up to a decade before cognitive symptoms. Accurately [....] » Read More
Title : Prosodic changes in patients with idiopathic parkinson’s disease: The effect of dysarthria severity
Miseon Kwon, Asan Medical Center, Korea, Republic of
Background & Objective: Patients with Parkinson’s disease frequently show hypokinetic dysarthria exhibiting both segmental and suprasegmental features of speech, such as monotonous pitch, reduced intensity, inappropriate pauses, slow or fast speech rate, and harsh voice [....] » Read More
Title : Validation study of the cogniscan computerized test for memory and processing speed in a Brazilian sample
Mariana Medeiros Assed, University of Sao Paulo, Brazil
To evaluate the psychometric properties of the Cogniscan screening test, a self-administered software for assessing episodic and working memory, focusing on validating its accuracy in a Brazilian clinical sample. Participants and Methods: This study involves 300 volunteers aged 1 [....] » Read More
Title : The efficiency of using clonidine buccally and dexmedetomidine intranasally as non-invasive procedural sedation during magnetic resonance imaging in patients hospitalized at the neonatology department in Ceske Budejovice
Martina Sivakova, Ceske Budejovice Hospital, Czech Republic
Backround: Procedural sedation does not have clear recommendations in the newborn population. There is an effort to find a balance between the need to minimize motion artifacts during imaging (including MRI) and the use of sedatives with the lowest possible adverse effects on the [....] » Read More