An analysis of 1200+ existing missense ACE mutations revealed that >400 are predicted to be damaging and led us to hypothesize that heterozygous carriers of these loss-of-function (LoF) ACE mutations (which result in low ACE levels) may be at risk for the development of late-o [....] » Read More
Parkinson’s disease (PD) is the second most common neurodegenerative disorders. Mutations in PINK1 and PARKIN lead to inherited forms of PD. My lab was one of the first in the world to report the function of the PINK1 gene, and to show that PINK1 and parkin function in a co [....] » Read More
In the last decade, a radically different scientific concept of developing Life on Earth - as BioRECURSION, or NeuroBLACKCHAIN - has emerged. From the point of view Life is Evolutional formation of Closed-Loop Coding-Decoding (CL-CD) chem-matter biochem procedure that appeared ~8 [....] » Read More
The process of apoptosis, a programmed form of cell death, is a normal occurrence during neurogenesis in the maturation of the central nervous system. However, dysregulated or premature activation of apoptosis can contribute to the pathogenesis of various neurodegenerative disord [....] » Read More
Background: Brain health is essential for cognitive, emotional, and behavioral functioning throughout life. The WHO's 2022 position paper emphasized the critical role of modifiable factors—such as physical activity, sleep, stress, and substance use—in maintaining [....] » Read More
Definition and Types: TBI is an injury to the brain caused by external force, resulting in a range of effects. It can be classified as mild (concussions), moderate, or severe based on symptoms and impact. Causes: Common causes include falls, vehicle accidents, sports injuries, [....] » Read More
The progression of neurodegenerative diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS), has been strongly associated with prolonged exposure to environmental neurotoxicants such as herbicides, weedicides, a [....] » Read More
Depression, a prevalent condition, has reached unprecedented levels in certain countries, such as Germany, as indicated by the most recent data. Depending on the severity of the condition and the patient's individual preferences, different treatment options are available. How [....] » Read More
The increasing prevalence of Alzheimer’s Disease (AD) necessitates effective diagnostic strategies for early intervention. This presentation examines the relationship between electroencephalography (EEG) and cerebrospinal fluid (CSF) biomarkers, highlighting their combined [....] » Read More
Growing evidence suggests a link between systemic inflammation and cognitive decline. Studies in cognitively healthy individuals have demonstrated an association between low-grade systemic inflammation, and accelerated cognitive decline. Furthermore, some research indicates a pot [....] » Read More
Brain tumors, especially glioblastoma, are highly malignant and lethal to humans. There is no rapid, non-invasive, early diagnostic method in the world. Recent reports indicate a major role of mucins in the pathogenesis of glioblastoma. Unfortunately, there is no method for rapid [....] » Read More
Introduction: The main aim of management of pediatric Severe Brain Injury (TBI) is to hold normal ranges for optimizing the most favorable outcomes.Clinical and research Institute of Emergency Pediatric Surgery and Trauma. Annually, more than 10000 children with head injury are c [....] » Read More
Transcranial photobiomodulation (t-PBM) is a novel, non-invasive, neuromodulation technique. It has a wide range of indications in neurodegenerative diseases including mild cognitive impairment (MCI), which serves as a potential preclinical stage of early Alzheimer’s diseas [....] » Read More
Language mediation, ranging from written translation to interpreting, represents one of the most complex cognitive tasks performed by the human brain which involves an intricate interplay of language processing, executive control, and working memory systems. The neural architectu [....] » Read More
Background: Recent research on Alzheimer’s disease (AD) has highlighted that the oxidative damage is the earliest event of disease. These oxidative modifications are closely associated with inflammatory molecules. It is necessary to explore these two pathways with AD pathop [....] » Read More
Aspartame, an artificial sweetener, is consumed by millions of people globally. There are multiple reports of aspartame and its metabolites affecting cognitive functions in animal models and humans, which include learning problems, headaches, seizures, migraines, irritable moods, [....] » Read More
Introduction: Traumatic brain injury (TBI) and Parkinson’s disease (PD) are major neurological disorders that significantly impact quality of life. Recent research suggests a potential link between them, particularly through the effects of repetitive mild traumatic brain in [....] » Read More
Introduction: Early detection of Alzheimer's disease (AD) is crucial for implementing timely interventions and improving patient outcomes. This study evaluates the efficacy of radiomics features extracted from T1-weighted magnetic resonance imaging (MRI) for the early de [....] » Read More
Background: Alzheimer’s disease is the most common cause of dementia in the elderly population. It is characterized by the accumulation of amyloid β and intraneuronal neurofibrillary tangles in the brain. Increasing evidence shows that the disturbance of insulin signal [....] » Read More
Background. Wernicke encephalopathy (WE) is a severe, potentially fatal neurological disorder caused by thiamine deficiency. While traditionally linked to alcoholism, non-alcoholic cases have emerged due to prolonged vomiting, malnutrition, and systemic diseases. This report pres [....] » Read More
A natural nutrition plan for elderly people with neurological disorders should focus on whole, nutrient-dense foods that support brain health and address specific needs. unprocessed foods that promote overall health and address age-related concerns. Remember to consult with [....] » Read More
Nutritional benefits: Quail eggs are rich in: Choline: Essential for brain health, cognitive function, and memory. Vitamin B12: Crucial for nerve function, brain health, and red blood cell formation. Omega-3 fatty acids: Anti-inflammatory effects, supporting brain healt [....] » Read More
Objective: Neurological disorders are increasingly prevalent in developing countries, particularly in sub-Saharan Africa. However, data regarding the epidemiology of these conditions in Somalia remain limited. This study aims to analyze the patterns of neurological diagnoses amon [....] » Read More
Parkinson's disease (PD) is a neurodegenerative disease characterized by death of dopaminergic neurons in the substantia nigra, affecting the brain`s ability to control movement and coordination. PD affects the brain, but disease pathology is systemic which is evident in peri [....] » Read More
Background: Although pediatric optic neuritis (PON) is a rare condition, current advancements in its diagnosis, investigation, and treatment suggest that a more precise risk assessment is necessary given the history of irreversible damage and functional degeneration of the optic [....] » Read More
Introduction: Multiple Sclerosis (MS) is the most common autoimmune disease affecting the central nervous system (CNS). It affects adults during their most productive years. The estimated prevalence of MS around the world is 20 per 100,000. Prevalence of MS in Saudi Arabia has be [....] » Read More
Objective: The atlantoaxial instability is a serious problem that can be solved in most recent studies posterior reduction and fixation surgery. There are many described techniques for C1-C2 fixation. In this work C1-C2 segmental screws was used aiming to study it.s efficenc [....] » Read More
Background: Intracranial hemorrhage following spinal surgery is an infrequent but severe complication. Due to its rarity, the etiology, clinical characteristics, and treatment have not yet been fully elucidated. It has been implicated due to intracranial hypotension secondary to [....] » Read More
Belarusian researchers have developed an algorithm for the clinical and laboratory diagnosis of dementia of various origins, based on the use of clinical indicators and laboratory studies of the concentration of biomarkers of the neurodegenerative process in the blood: β-amy [....] » Read More
Introduction: Botulinum toxin (Botox) is widely used in beauty industry and its long-term consequences can be a matter of concern. The hippocampal cholinergic system plays a significant role in memory and learning that could be affected by Botulinum toxin. However, to date, the e [....] » Read More
Objective: This pilot study explores cognitive changes over time using Cogniscan, a neuropsychological screening tool. The aim was to assess variations in attention, intelligence, and memory performance in a postgraduate student between two assessments conducted one year apart, p [....] » Read More
To evaluate the psychometric properties of the Cogniscan screening test, a self-administered software for assessing episodic and working memory, focusing on validating its accuracy in a Brazilian clinical sample. Participants and Methods: This study involves 300 volunteers aged 1 [....] » Read More
Introduction: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that benefits significantly from early diagnosis and treatment. This study evaluates the efficacy of radiomics features extracted from T2-weighted magnetic resonance imaging (MRI [....] » Read More
The way we perceive our world directly influences our responses to it. There is significant variability in how individuals perceive and subjectively evaluate their environment, even among people experiencing the same conditions. In a healthy human system, perception and response [....] » Read More
Patients with psychogenic nonepileptic seizures (PNES), also known as Functional Seizures (FS), have involuntary paroxysmal episodes that resemble epileptic seizures but without organic etiology. Patients with PNES are frequently misdiagnosed and mistreated for epileptic seizures [....] » Read More
The incidence of Traumatic spinal cord injuries (TSCI) is small and ranges between 10-50/million population/year. Prior to the second WW the great majority of patients died within two years of injury. Since the 2nd WW, due to the efforts of the pioneers who dedicated their profes [....] » Read More
The presentation starts by addressing the fields of neurobiology, especially concentrating on the future of neurobiology and the future, connectivity and connectomics. The discussion will also include genetics and neurobiology. Artificial Intelligence and Machine Learning will be [....] » Read More
In 1906, the Italian biologist and pathologist Camillo Golgi and the Spanish pathologist and histologist Santiago Ramón y Cajal shared the Nobel Prize for Medicine and Physiology ‘in recognition of their work on the structure of the nervous system’. They are co [....] » Read More
As the world’s population ages, Cognitive Frailty (CF) is becoming one of the most serious health problems and elucidating its biological mechanisms along with prevention and treatments becomes increasingly important also considering the associated health costs. We thus per [....] » Read More
Gamma-Amino Butyric Acid (GABA) is the main inhibitory neurotransmitter in the brain and GABA-ergic transmission is important for the regulation of learning and memory. The progesterone metabolite allopregnanolone (Allo) is a potent positive allosteric GABA-A Receptor Modulating [....] » Read More
Objective: To investigate the effect of and Acupuncture on brain plasticity and motor development in children with cerebral palsy. Investigate effect on mechanism of apoptosis of brain nerve cells, regulating the expression of neurotrophic factors, promoting the remodeling o [....] » Read More
Brain cancer and its treatments bring a unique threat to the patient’s identity and quality of life by challenging their essential identity in significant ways, possibly including impaired cognitive skills, loss of memory, reduced coordination, altered feeling states, and l [....] » Read More
Background: General studies of neurocognitive processing across the lifespan have demonstrated gradual declines among healthy adults in the domains of memory, problem-solving, executive functioning, and processing speed. However, a number of specific factors have been [....] » Read More
Transcranial magnetic stimulation (TMS) has emerged as a non-invasive neuromodulation technique capable of inducing neuroplasticity, with significant potential in both basic research and clinical applications. This presentation will explore the application of various TMS protocol [....] » Read More
This case report highlights how Stiff Person Syndrome (SPS) can be associated with severe complications, including heterotopic ossification (HO). HO of skeletal muscle has not been described in the pathophysiology of SPS and has been described in only one other case report of SPS [....] » Read More
Sleep serves a vital restorative function, yet the precise mechanisms underlying brain activity during sleep deprivation remain unclear. Alpha waves (8-12 Hz), typically associated with relaxed wakefulness, also appear in various sleep stages, particularly during the transition f [....] » Read More
Ulnar nerve entrapment across the elbow (UNEAE) and across wrist (UNEAW) is the second most common entrapment of the hand after carpal tunnel syndrome. There are few gradings available for UNEAE and lesser in UNEAW. The aim of this research is: To create a clinically appro [....] » Read More
Further research into the genetic code and its physical properties is an important resource for decoding the neurocode and developing strong artificial intelligence. DNA has a hierarchical spiral structure, which still remains outside of the attention of science. Meanwh [....] » Read More
Chronic pain is defined as persistent pain for more than three months, resulting in changes in the functional synaptic network of the brain and its gray matter dimensions, causing hypersensitivity to a nociceptive stimulus and increased excitability of the nodal stress mechanism, [....] » Read More
Anxiety and depression are major causes of disability worldwide, often worsened by chronic stress. Schinus terebinthifolia Raddi (SteLL) has been traditionally used for various medicinal purposes, including treating depression with bark-and-leaf tea or leaf decoction. Previous st [....] » Read More
Introduction: Migraine is a common neurological condition that triggers chronic and debilitating pain, significantly affecting the quality of life of those affected. Moreover, magnesium supplementation has emerged as a promising strategy for reducing migraine episodes, due to its [....] » Read More
Nonsurgical treatments, such as nerve block, in chronic pain patients with severe adhesions are reported to have a relatively low effect and a high risk for relapse. This may be attributed to the fact that epidural adhesions themselves are difficult to remove through such methods [....] » Read More
Background: Lymphomas are malignant neoplasms of the immune system, originating in lymphoid organs and having the potential to affect the central nervous system. Notably, lymphomas presenting initially as acute myelitis are extremely rare. Most of these cases exhibit symptoms of [....] » Read More
Purpose: Opioid use disorder (OUD) is distinguished by its high relapse rates and intricate neuropsychological mechanisms, with conventional therapies exhibiting limited efficacy. The present study aims to evaluate the effectiveness of a neuroplasticity-targeted cognitive interve [....] » Read More
Neurodegenerative diseases such as Parkinson’s and Alzheimer’s are progressive, incurable disorders characterized by the degeneration of nerve cells. This deterioration leads to a gradual decline in mental and physical health. One key factor in neurodegeneration is th [....] » Read More
Background: The Neurocognitive Rehabilitation theory serves as the basis for Cognitive Multisensory Rehabilitation in stroke patients. The neurocognitive approach to rehabilitation is based on theories of motor control and learning aiming to facilitate Neuroplasticity&n [....] » Read More
Comparative developing brain histo-anatomical pathologies of Fluoride ions and Bifenthrin in-ovo exposures were explored in the golden black variety of domestic chick. Three exposure groups were –the Vehicle control group (Vg); Fluoride (F) group and the Bifenthrin (Bn) gro [....] » Read More
Alcohol Use Disorder is a chronic disease that causes an individual to lose control of their ability to stop drinking, diagnosed by state markers and biomarkers. We analyzed a publicly available RNA-seq dataset comparing patients with Alcohol Dependence (now AUD) to controls. We [....] » Read More
Objectives: Proper name anomia is a common language deficit observed in patients with dementia, impacting their ability to recall and retrieve names of familiar people. This study investigates the neural changes associated with a 6-week proper name anomia therapy program in patie [....] » Read More
Background: Epilepsy is a disease that affects over 50 million people globally. It poses significant challenges, especially for those with drug-resistant forms. This study aims to evaluate the efficacy of transcutaneous vagus nerve stimulation (t-VNS) in treating drug-resist [....] » Read More
Background: Subacute sclerosing panencephalitis (SSPE) is a rare, fatal complication of persistent measles virus infection. It typically affects children but can rarely present in adults with an aggressive course. Case Report: A 22-year-old male presented with rapidly progress [....] » Read More
Neurology deals with functioning of brain and spinal cord. It also controls activities related to brain particularly in humans. Neurology is also known as Neuroscience that deals with all perspectives related to Mind and Body. Psychology is a science that deals with the mind and [....] » Read More
Melatonin is recognized for its ability to regulate the body's circadian rhythms, which govern the sleep-wake cycle. However, it also possesses powerful antioxidant and anti-inflammatory properties, making it a promising candidate for mitigating the neurotoxic effects of heav [....] » Read More
A population of neurons modeled by a frustrated array of Josephson junctions has memory. The array can be thought of as a spin chain, say two dimensional. The dynamics tries to minimize the energy, and this requires the spins to point in the same direction. Frustration, [....] » Read More
Frontal Alzheimer’s disease (fAD) is an atypical AD variant which is difficult to differentiate from and frequently misdiagnosed as behavioural variant frontotemporal dementia (bvFTD). Most recent work has identified two subtypes of fAD: a behavioural subtype (bAD) associat [....] » Read More
Background and aims: Creutzfeldt-Jakob disease (CJD) is a rare, fatal neurodegenerative prion disorder often mimicking other neurological conditions including stroke. This case report highlights the diagnostic challenges in a patient with CJD initially presenting with non specifi [....] » Read More
Background: Muscular dystrophies (MDs) are progressive neuromuscular disorders causing severe disability and premature mortality in children. Traditional treatments have focused on symptom management, but gene therapy offers a paradigm shift. Techniques like adeno-associated vira [....] » Read More
The importance of the adrenergic transport mechanisms comprehension in the synapses is useful in clinics diagnosis and pharmacology. For this aim, the paper proposes a parallel biodevice composed by Adrenaline Bioliquid On Insulator. Between the Source and Drain of the device is [....] » Read More
Background: Medulloblastoma is the most common malignant brain tumor in children, but its pathogenesis is unknown and there is a lack of early diagnostic markers or effective therapeutic targets. circRNA is a class of endogenous non-coding Rnas that regulate gene expression in eu [....] » Read More
Introduction: Cerebral infarctions (CI) in young people represent a pathology whose incidence is increasing worldwide. The particularity of this young population lies in the diversity of risk factors, as well as in the etiologies incriminated. The main objective of our study was [....] » Read More
Introduction: Diabetes is a disease characterized by impaired insulin secretion and/or function. Ezetimibe is a lipid-lowering drug widely used for the treatment of hypercholesterolemia. This study investigates the impact of ezetimibe on nitric oxide level and its effects on diab [....] » Read More
Objective: It has been shown that the AMPK signaling pathway helps maintain the structure of nerve cells and prevent damage caused by hypoxia by preserving the energy available in these cells. This signaling pathway is activated by various drugs, including metformin. Methods: [....] » Read More
Objectives: To compare the prevalence of cerebral palsy (CP) among populations with different ethnic compositions in the Lankaran region. Methods:This study is based on official statistical data on CP cases recorded during the first four years of life among children born betwe [....] » Read More
Background: Parkinson’s disease (PD) remains challenging because of subjective clinical assessments and late-stage symptom manifestation. Retinal optical coherence tomography (OCT) biomarkers reflect neurodegenerative changes and provide a noninvasive diagnostic tool. This [....] » Read More
Background: The new coronavirus infection not only affects various organs and systems of the human body, but also leads to deterioration in various areas of cognitive functions. After the 12th week of the new coronavirus infection, some children continue to have or develop variou [....] » Read More
Title : Essential roles, mechanisms and consequences of vascular dementia
Yong Xiao Wang, Albany Medical College, United States
Vascular contributions to cognitive impairment and dementia (VCID) is a common neurodegenerative disease. This dementia includes all types of vascular dementia. It is caused by brain cerebral blood vessel dysfunctions. VCID has high morbidity and mortality. Diabetes is a leading [....] » Read More
Title : Who cares …… for the carers
Jaqueline Tuppen, COGS Club, United Kingdom
The House of Commons Inequalities in Dementia Care Debate 2024 highlighted that in the whole of the UK, the number of people with dementia is estimated at 850,000 and in England, around 540,000 people care for an individual with dementia. These numbers are replicated around [....] » Read More
Title : The foundation and architecture of Personalized & Precision Medicine (PPM) in clinical neurology: Towards curative and neurodegenerative disease-modifying treatment for multiple sclerosis
Sergey Suchkov, R&D Director of the National Center for Human Photosynthesis, Mexico
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, Personalized and Precision Medicine (PPM). PPM is an emerging approach to healthcare that aims to optimize medical treatment by tailoring it to the specific character [....] » Read More
Title : Vascular effects during neuroinflammation
David Lominadze, University of South Florida, United States
Many neuroinflammatory diseases are accompanied by neurodegeneration and memory deficits. In a substantial number of these diseases, deleterious causes originating in vasculature play a significant role in the development and/or progression of morbidity. Traumatic brain injury (T [....] » Read More
Title : Neurophenomenology in retraining musicians with task-specific focal dystonia: Three cases
Sang Hie Lee, University of South Florida, United States
Musicians experience a high rate of playing-related pain and injury due to the rigorous nature of repetitive mind-body training, specifically musculoskeletal disorders (PRMD), performance anxiety (PA), and task-specific neurological disorder (TSND). TSND is the least understood b [....] » Read More
Title : The loss of PINK1 function alters molecular pathways in human fibroblasts
Yingxue Ren, Mayo Clinic, United States
Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Mutations in the PINK1 and PRKN genes have been linked to early-onset PD and are among one of the most frequent causes for inherited, recessive PD. PINK1 and PRKN together eliminate damaged mitoc [....] » Read More
Title : Local audit of use of opioids in patients with headaches in secondary care
Olga Tanda, Great Western Hospital NHS Foundation Trust, United Kingdom
This study examines the concerning trend of opioid prescribing for headache management in Acute Medicine Units (AMU), Same Day Emergency Care (SDEC), and Emergency Departments (ED), practices that contradict the recommendations outlined in NICE guideline CG150. Opioid use for hea [....] » Read More
Title : FHTH: Find the Headache, Treat the Headache – diagnosis and management of headache in acute, a re-audit
Olga Tanda, Great Western Hospital NHS Foundation Trust, United Kingdom
Headaches are a prevalent neurological condition that significantly impacts patient quality of life and healthcare resources. A concerning trend of frequent readmissions for headaches prompted the Urgent Care multidisciplinary team to analyze current diagnosis and management prac [....] » Read More
Title : Increasing Sudden Unexpected Death in Epilepsy (SUDEP) documentation in paediatric epilepsy clinics
Rachel Earley, Kings College London, United Kingdom
Background: Sudden Unexpected Death in Epilepsy (SUDEP) affects 1.2/1000 children in the UK. Within the last year, at Darent Valley Hospital (DVH) there have been 3 SUDEP related deaths. Despite this, SUDEP discussions are not consistently documented in clinics. We completed a Qu [....] » Read More
Title : The absolute beginner. Right-and lefthand process-based measures in handwriting
Carlo Di Brina, Sapienza University of Rome, Italy
Fine motor performance across ages is traditionally assessed through handwriting and drawing, focusing on both the final product and the kinematic aspects of the movement (Blank et al., 2019; Smits-Engelsman et al., 2001; van Drempt et al., 2011). In kinematic analysis, tablet-ba [....] » Read More
Title : Increased pain sensitivity and musculoskeletal impairments in migraine patients
Stefano Di Antonio, Genetics and Maternal Child Health, Italy
This presentation is based on the scientific debate on whether increased pain sensitivity (IPS) and cervical musculoskeletal impairments (CMI) can be considered a psychophysical manifestation of migraine, and how these characteristics could be used to identify thereby different m [....] » Read More
Title : A critical appraisal of strategies to afford protection against neurotoxic amyloid β peptides-induced brain degeneration
Carlos Gutierrez Merino, University of Extremadura, Spain
The 2022 world Alzheimer’s report pointed out the importance of early detection and diagnosis of Alzheimer’s disease (AD), as nearly 75% of individuals with dementia are not diagnosed globally. The histopathological hallmarks of AD are the extracellular amyloid-β [....] » Read More
Title : Interactions between COX-2 and glutamatergic receptors with CB1 as a novel target in mood and cognitive studies
Katarzyna Stachowicz, Polish Academy of Sciences, Poland
Glutamate, the brain’s primary excitatory neurotransmitter, maintains neuronal communication and functional stability. Together with gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter, it establishes a balance essential for cognitive processes, emotiona [....] » Read More
Title : Cognitive enhancement effect of auricular vagal nerve stimulation in patients with mild cognitive impairment and alzheimer’s disease
Adam Broncel, Neuromedical, Poland
Background: The modulatory role of the vagal nerve on the central nervous system (CNS) has been discussed for decades. Currently, vagal nerve stimulation (VNS) is recognized as a low-risk intervention and a clinically viable procedure for patients suffering from a broad spectrum [....] » Read More
Title : Targeting the endocannabinoid system: A novel approach to the treatment of traumatic brain injury and stroke
Esther Shohami, The Hebrew University of Jerusalem, Israel
Cannabis is one of the most widely used plant drugs in the world and was used for millennia for its medicinal and mind-altering effects. The latter are known to be mediated via the activation of the endocannabinoid (eCB) receptor CB1. Developments in medicinal chemistry of novel [....] » Read More
Title : Scientific-technological integration towards the clinical rehabilitation of spinal cord injured individuals
Alberto Cliquet Junior, UNICAMP, Brazil
Individuals with spinal cord injury rarely have access to innovative technology. The work presented here has allowed sensorimotor recovery to paraplegics and tetraplegics, in addition to the production of cutting-edge technology for control of upper and lower limbs. Neuromuscular [....] » Read More
Title : Fibromyalgia treated with Transcranial Direct Current Stimulation (tDCS) and physical exercise
Milton C R Medeiros, Irmandade Santa Casa de Arapongas PR, Brazil
Introdution: Fibromyalgia is a chronic and heterogeneous condition, characterized by diffuse musculoskeletal pain and associated changes, such as anxiety disorder, sleep disorder, depression, cognitive impairment and fatigue {1}. Fibromyalgia is a frequent cause of pain and [....] » Read More
Title : Antibody-Ppoteases as the upgraded translational tools of the next-step generation in personalized and precision practice to monitor multiple sclerosis at clinical and subclinical stages
Sergey Suchkov, R&D Director of the National Center for Human Photosynthesis, Mexico
Among the best-validated predictive biomarkers are autoimmunity-related ones to predict and prognosticate risks of the chronification, complications and thus disabling. The latter is so much valuable and important since chronic autoimmune inflammation course is structured to cons [....] » Read More
Title : Neuromedin U induces airway goblet cell hypersecretion through eosinophil-derived interleukin-1α in allergic rhinitis
Changqing Zhao, Shanxi Medical University, China
Background: Neuropeptide neuromedin U (NMU) is elevated in allergic rhinitis (AR) and has been linked to eosinophil activation, but its role in goblet cell (GC) secretion during AR remains unclear. This study aimed to investigate whether NMU induces GC hypersecretion. Methods: [....] » Read More
Title : Neuroimmune mechanisms in nasal hyperreactivity: Unraveling the nose-brain axis
Yanjie Wang, Shanxi Medical University, China
Nasal hyperreactivity (NHR), including conditions such as allergic rhinitis, represents a group of common disorders characterized by complex neuroimmune interactions, with underlying mechanisms that are not fully understood. Communication between the nervous and immune systems pl [....] » Read More
Title : The clinical features of children with autism spectrum disorder in India
Rahul Hajare, Sandip University, India
Ng the children’s sex and age and the children’s parents’ age and education level, when a diagnosis was determined. We also studied clinical features, including the child’s age at the time of early alert signs and at diagnosis, the core alert sign and symp [....] » Read More
Title : Inflammatory profile and alpha-synuclein in Egyptian alzheimer’s and parkinson’s disease patients: A pilot cohort study
Gharib Fawi Mohamed, Sohag University, Egypt
Alzheimer’s and Parkinson's disease are the most common neurodegenerative diseases. With the aging of the general populations, the prevalence of these diseases is on the rise .The imperative for early detection, non- invasive, cost effective biomarkers to reflect diseas [....] » Read More
Title : Sensory processing disorder and its effect on children's skills and development in autism disorders, attention deficit hyperactivity disorder and learning disabilities: A review article
Navid Mirzakhani, SBMU University, Iran (Islamic Republic of)
Introduction: Sensory processing is an important stage in performance during which the organization and interpretation of received messages is Done, and finally the final decision is made. Development in an efficient sensory-perceptual-motor processing system plays an essential r [....] » Read More
Title : Phosphorylation of Kv7.2 potassium channel’s regulatory domain alters binding interactions with calmodulin
Sinchana Basoor, UT Health San Antonio, United States
Kv7 channels are potassium ion channels expressed in the nervous system. Kv7 channels function to control the excitability of neurons by reducing the rate of action potential firing. The Kv7.2 channel has been shown to play a particularly crucial role in neurodevelopment. Five di [....] » Read More
Title : Brain aquaporin expression in development and disease
Randall Woltjer, Oregon Health and Science University, United States
Aquaporins (AQPs) are channels that participate in water homeostasis in various organs including the kidney and brain. Several classes of these including AQP1, AQP4, and AQP9 are expressed, chiefly by glial cells, in the healthy human brain in a region-specific manner. Cerebral c [....] » Read More
Title : Deepthickness: A novel deep learning method for estimating cortical thickness trajectories in healthy and alzheimer’s disease populations
Connor Dalby, University of Glasgow, United Kingdom
Alzheimer's disease (AD) is a neurodegenerative disease that presents with critical challenges in diagnosis and treatment. Emerging research indicates that AD-related cortical changes, such as cortical thickness, can appear up to a decade before cognitive symptoms. Accurately [....] » Read More
Title : The efficiency of using clonidine buccally and dexmedetomidine intranasally as non-invasive procedural sedation during magnetic resonance imaging in patients hospitalized at the neonatology department in Ceske Budejovice
Martina Sivakova, Ceske Budejovice Hospital, Czech Republic
Backround: Procedural sedation does not have clear recommendations in the newborn population. There is an effort to find a balance between the need to minimize motion artifacts during imaging (including MRI) and the use of sedatives with the lowest possible adverse effects on the [....] » Read More
Title : Impact of egg-derived proteins, yolkin polypeptide complex and ovocystatin, on blood-brain barrier integrity and function
Bartlomiej Stanczykiewicz, Wroclaw Medical University, Poland
Introduction: The blood-brain barrier (BBB) is a highly selective and protective membrane that separates the brain from the circulating blood, effectively shielding it from harmful substances, toxins and pathogens. Its primary function is to maintain brain homeostasis, regul [....] » Read More
Title : Improvement of brain function by wasabi component “hexaraphane”
Isao Okunishi, Kinjirushi Co Ltd, Japan
Hexaraphane (6-methylsulfinylhexyl isothiocyanate; 6-MSITC) is an isothiocyanate present in the rhizomes and roots of Wasabi (Eutrema japonicum (Miq.) Kiudz.). Here we present the results of two clinical trials conducted on healthy subjects and patients with chronic fatigue syndr [....] » Read More
Title : Association of ocular surface disease with psychiatric or neurological disorders in elderly patients
Shabbir Saifuddin, Jansons Hospital, United Arab Emirates
Ocular Surface Disease / Dry eye disease (DED) is a common disease that can impair quality of life significantly. Its prevalence increases with advancing age, and the economic burden of the disease on both a patient and the society is increasing with elongation of life expectancy [....] » Read More
Title : Investigating brahmi's neuroprotective effects in chronic traumatic encephalopathy: Insights from a mouse model
Nitesh Kumar Gupta, Banaras Hindu University, India
Introduction: Chronic Traumatic Encephalopathy (CTE) is a progressive neurodegenerative disorder resulting from repetitive head injuries, often seen in athletes and military personnel. The condition is characterized by the accumulation of hyperphosphorylated tau protein, lea [....] » Read More
Title : The effect of educational intervention based on precede model to reduce the anxiety of nurses in the hospitals of Tehran University of Medical Sciences
Davoud Shojaeizadeh, Tehran University of Medical Sciences, Iran (Islamic Republic of)
People who work in hospitals such as nurses have many stress and they are exposed to anxiety disorders. The aim of this study is to determine the effect of applied relaxation based of PRECEDE Model to reduce anxiety of nurses. In this interventional study, 40 nurses as control gr [....] » Read More
Title : A survey on respiratory and neurological symptoms in alzheimer's, schizophrenia, bipolar, and migraine patients following COVID-19 infection
Arash Letafati, Tehran University of Medical Sciences, Iran (Islamic Republic of)
Introduction: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019 led to the global Coronavirus disease 2019 (COVID-19) pandemic with varied clinical symptoms. Neurological complications have been a significant concern, with diverse symptoms and [....] » Read More
Title : Prosodic changes in patients with idiopathic parkinson’s disease: The effect of dysarthria severity
Miseon Kwon, Asan Medical Center, Korea, Republic of
Background & Objective: Patients with Parkinson’s disease frequently show hypokinetic dysarthria exhibiting both segmental and suprasegmental features of speech, such as monotonous pitch, reduced intensity, inappropriate pauses, slow or fast speech rate, and harsh voice [....] » Read More