Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundreds of FDA approved medical products. While nanomedicine has been around for several decades, new technological advances are pushing its boundaries. For exa [....] » Read More
Treatments of patients with severe therapy-resistant dementia and depressive disorders repeatedly pose enormous challenges in psychiatry and neurology. Transcranial pulse stimulation (TPS) as a new non-invasive therapy method could represent a new alternative to standard treatmen [....] » Read More
Purpose: To evaluate the relationship between Meniere’s disease and chronic cerebrospinal venous insufficiency (CCSVI) using ultrasonography, magnetic resonance imaging, and venography and the effectiveness of angioplasty for reducing the symptoms of inner e [....] » Read More
It has been recently shown that nutritional ketosis is effective against seizure disorders and various acute/chronic neurological disorders. Physiologically, glucose is the primary metabolic fuel for cells. However, many neurodegenerative disorders have been associated with impai [....] » Read More
Background: Climate change is accompanied by an increasing role of environmental factors as risk factors for the occurrence of emergency states including ones of the nervous system. This problem becomes particularly significant in the southern regions, where there are condit [....] » Read More
Predicting outcomes of postanoxic states, especially concerning motor function control, is a crucial aspect of the rehabilitation process. This series of clinical observations presents the reorganization of cortical motor representations (primary motor cortex, premotor cortex, su [....] » Read More
In recent years, there has been an increase in the number of patients with speech development disorders, respectively, and with cognitive deficits. The identification of the etiology and pathogenetic mechanisms of speech disorders is an important task and is necessary to determin [....] » Read More
Background: Cryptococcal Meningitis (CM) is the most common central nervous system infection (CNSI) among patients with severe immunodeficiency syndrome secondary to human immune deficiency virus. Co-infection with other CNSI is relatively common especially with TB meningitis and [....] » Read More
Neurological disorder is a factor that affects learning. A Learning Disability is said to be a neurological disorder. A ‘learning disability’ results from a difference in the way a person’s brain “is wired”. Children with Learning Disa [....] » Read More
Innocent smile is a natural transition that consists of biological and psychological changes that occur for children. ADHD, painful, is a common condition of pain that affects a wide range of young children capable of reducing their quality of life, decrease their ability to func [....] » Read More
Chronic refractory headache is challenging clinical entity because management is complex and unsastisfactory. Idiopathic intracranial hypertension is a disorder causing chronic refractory headache that results in isolated increase in intracranial pressure. Among aytpical presenta [....] » Read More
Introduction: Autoimmune Encephalitis (AIE) is closely associated with antibodies against neuronal cell-surface proteins, receptors, and ion channels. However, some forms of disorder have no known antibody presently. In children neurological manifestations are prominent init [....] » Read More
The disorder of the development of the SN during the embryonic period is at the origin of malformations of cortical development (MDC) which represent a major cause of mental and motor disabilities as well as severe eilepsy. We describe here a syndrome called Kiza-Ntenga syndrome [....] » Read More
Introduction: Circadian rhythms are regulated by genetic and environmental components. The association of intrinsic and extrinsic factor modulates physiological and individual sleep schedules sleep hygiene and even different chronotype. Evidence suggests evening-type individ [....] » Read More
Objectives: This study aimed to analyze an electromechanical stance control (SC) knee joint, 'sensor lock', which could potentially solve the problems of walking and energy expenditure in subjects with quadriceps weakness. Methods: Nine subjects with quadriceps [....] » Read More
Non-linear dynamic analysis has been widely used for physiological signals, and the interesting point is the analysis of the EEG signal of an Alzheimer's patient by this method [2]. The relationship between the non-linear characteristics of the EEG signal of Alzheimer's p [....] » Read More
Accurately extracting brain tissue is a critical and primary step in brain neuroimaging research. Due to the differences in brain size and structure between humans and nonhuman primates, the performance of the existing tools for brain tissue extraction, working on macaq [....] » Read More
Background: Following traumatic brain injury (TBI), inhibition of the NKCC1 cotransporter has been observed to alleviate damage to the Blood-Brain Barrier (BBB). However, the underlying mechanism for this effect remains unclear. This study aimed to investigate the mechanisms [....] » Read More
Background: Atypical dementias often go unrecognized in everyday clinical practice. In 1988, Frank Benson and colleagues first described a case series of 5 patients with progressive visual complaints in the form of Balint's syndrome (visual ataxia, ocular apraxia, simult [....] » Read More
Non-invasive brain stimulation techniques hold promise for addressing the cognitive decline associated with Alzheimer's disease (AD). Recent research did reveal significant immediate cognition-enhancing effects of both rTMS and tDCS in AD, with rTMS also showing beneficial lo [....] » Read More
Transcranial Pulse Stimulation (TPS) is a non-invasive procedure for the treatment of patients with Alzheimer's disease. Alzheimer is the most current form of dementia, affecting millions of patients worldwide. As a neurodegenerative disease, it is associated with a prog [....] » Read More
rTMS (repetitive transcranial magnetic stimulation) is yet a well know neurostimulation technique, which is now challenged by TPS (transcranial pulse stimulation). TMS has been investigated since around 40 years and conquered an undisputed place in clinical treatment, most of all [....] » Read More
A 12-year-old girl presented to the neurology department with complaints of difficulty in walking for 3 years. Parents noticed slurred speech and posturing of fingers and toes while walking since 2years. She was born of consanguineous parentage. She had normal motor and mental mi [....] » Read More
Stroke is a leading cause of morbidity and second cause of mortality worldwide. Early participation in rehabilitation treatments such as neurostimulant drugs showed to be beneficial. Amantadine usually used as Parkinson disease treatment, is prescribed in patients with traumatic [....] » Read More
Background and Aims: Patent Foramen Ovale (PFO) has been associated with Embolic Stroke of Undetermined Source (ESUS) . It remains uncertain whether PFO is the direct etiology or an incidental finding. The aim of our study was to analyze the incidence and characteristi [....] » Read More
Congenital heart defect (CHD) is the most common of all congenital defects, affecting nearly 1% of live births. Brain injuries and adverse neurodevelopmental outcomes after pediatric heart surgery remain a dominant focus of improving clinical care Cerebral injury resulting f [....] » Read More
A Case ReportIntroduction Marcus Gunn syndrome is a rare genetic condition that combines congenital neurogenic ptosis with mandibulopalpebral synkinesis. This synkinesis involves the involuntary elevation of the drooping upper eyelid during certain mandibular movements, particula [....] » Read More
Objective: To analyse the clinical and radiological outcomes in patients receiving adjuvant gamma knife radiosurgery (GKRS) / radiotherapy (RT) for residual and recurrent craniopharyngiomas, and compare outcomes with patients who did not receive any postoperative radiotherapy. [....] » Read More
Malignant Glioblastoma Multiforme is the most aggressive of the gliomas, a collection of tumors arising from glia or their precursors within the central nervous system. It accounts for 17% of all primary brain tumors which makes GBM the most common malignant brain tumor. Even wit [....] » Read More
Creutzfeldt Jakob disease (CJD) is a fatal transmissible spongiform encephalopathy (TSE) similar to diseases occurring in animals. Management of these diseases has been a disaster over the past fifty years since there has been total reliance on a flawed theory regarding pathogene [....] » Read More
Fortunately the incidence of Traumatic Spinal Cord Injury (TSCI) is rare 10-50/million population/year. Trauma to the spinal cord however results in a multi-system physiological impairment and malfunction, paralysis, sensory loss and a potential wide range of medical and non-medi [....] » Read More
Objective: To investigate the effect of and Acupuncture on brain plasticity and motor development in children with cerebral palsy. Investigate effect on mechanism of apoptosis of brain nerve cells, regulating the expression of neurotrophic factors, promoting the remodeling of ner [....] » Read More
Gamma-amino butyric acid (GABA) is the main inhibitory neurotransmitter in the brain and GABA-ergic transmission is important for the regulation of learning and memory. The progesterone metabolite allopregnanolone (Allo) is a potent positive GABA-A receptor modulating steroid (GA [....] » Read More
Patients with psychogenic nonepileptic seizures (PNES), also known as Functional Seizures (FS), have involuntary paroxysmal episodes that resemble epileptic seizures but without organic etiology. Patients with PNES are frequently misdiagnosed and mistreated for epileptic seizures [....] » Read More
It has been noted by multiple researchers that there is Spontaneous Electrical Activity (SEA) at painful trigger points. This author has studied chronic muscle spasm and found that SEA is always present and appears to be the cause for the chronic nature of muscle spasm and result [....] » Read More
The amyloid b (Ab) peptide is a major hallmark of Alzheimer’s disease (AD). The 42- and 40-amino acid peptides (Aβ1-42, Aβ1-40) are the most prevalent toxic Aβ species, but the pyroglutamylated forms (AβpE3-42, AβpE3-40) also occur in large quantiti [....] » Read More
Glioblastoma (GBM), grade IV glioma, is the most prevalent/malignant primary brain tumor in adults. The therapeutic benefit from standard treatment remains limited and median survival of GBM patients is around 15 months. Glioblastoma stem cell-like cells (GSCs) are a su [....] » Read More
The present review aimed to establish an understanding of the pathophysiology of leptomeningeal disease as it relates to late-stage development among different cancer types. For our purposes, the focused metastatic malignancies include breast cancer, lung cancer, melanoma, primar [....] » Read More
Injury and disease can lead to a myriad of neural control problems (e.g., following spinal cord injury or stroke). Rehabilitation is a leading therapy for patients, but it only leads to modest neural plasticity & recovery. Targeted plasticity therapy (TPT) is an emerging ther [....] » Read More
Background: Guillain Barre syndrome (GBS) is a very well-studied condition in neurology which usually associated with antecedent infections, predominantly gastroenteritis or chest infection over the past few weeks. Among its variants, acute motor and sensory axonal neuropath [....] » Read More
Ulnar nerve entrapment across the elbow (UNEAE) and across wrist (UNEAW) is the second most common entrapment of the hand after carpal tunnel syndrome. There are few gradings available for UNEAE and lesser in UNEAW. The aim of this research is to create a clinically appropriate u [....] » Read More
The grading systems proposed by Bland and Padua are the most commonly used are very old and and both have limitations. The aim of this research is to establish, using the best available evidence, a clinically appropriate revision of the current CTS nerve conduction grading tool, [....] » Read More
Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons and the presence of intracellular inclusions, named Lewy bodies that are mainly composed of misfolded proteins. The accumulation of misfolded proteins is a molecu [....] » Read More
Parkinson's disease (PD), after Alzheimer's, is the second most important age-related neurodegenerative disease whose prevalence and incidence increase almost exponentially with age and reach a peak after the age of 80. PD is primarily characterized by a selective loss of [....] » Read More
Parkinson's disease (PD) stands out as one of the most prevalent neurodegenerative conditions, typically manifesting in later stages of life, characterized by the gradual deterioration of motor functions. Recently identified environmental factors either increase the risk or d [....] » Read More
Considerable interest has been, and still is, generated by the potential performance enhancing benefits of EEG biofeedback or Neurofeedback training (NFT). A plausible rationale for such training, with an aim to improve mood and or enhance cognition, can be made based upon what i [....] » Read More
Currently, most clinical practice and scientific research revolves around a single disease or system, and the single disease-oriented diagnostic and therapeutic paradigm needs to be broken. This review describes how transcutaneous auricular vagus nerve stimulation (taVNS), a nove [....] » Read More
Although the incidence of unruptured intracranial aneurysms (UIA) ranges from 2% to 5%, aneurysm rupture is a critical and critical condition in neurosurgery, posing a fatal threat to patients. The burden of UIA is considerable in stroke patients. However, the best prev [....] » Read More
Objectives: To compare the protein coding transcripts differences before and after different induction time of adipose-derived stem cell (ADSC)-induced Schwann-like cells (iSCs). Methods: Isolation of ADSCs from healthy adult female rats was performed. The iSCs of 7 days and 1 [....] » Read More
The gene encoding the biological enzyme N-acetyltransferase 1 (NAT1) plays a crucial role in the malignant progression of various tumors. As the most common and poorly prognostic malignant brain tumor, this study explored the relationship between NAT1 expression changes in glioma [....] » Read More
The escalating prevalence of particulate matter (PM) has prompted significant apprehensions regarding its detrimental impact on human health. This research delves into the potential of FBBR in alleviating the effects induced by PM2.5 in both SH-SY5Y cells and mice exposed to PM2. [....] » Read More
Background: Caffeic acid phenethyl ester is found in honey bee propolis. It has immunomodulatory, anti-inflammatory and anti- cancer properties. Rotenone is a pesticide commonly used for inducing experimental Parkinson’s disease (PD) due to complex I inhibition and microgli [....] » Read More
Memory is retrieved from the different cortex through the memory retrieval circuit. This circuit involves psychical cortex which convert them and comprehend them and send to motor speech area and person recognize it. Memory retrieval process Memory retrieval c [....] » Read More
Background: Periodic discharges in electroencephalograms (EEGs) represent rhythmic wave patterns and can signal acute or subacute brain damage. While they may predispose patients to seizures, not all are epileptiform. This study focuses on electrographical periodic discharges and [....] » Read More
Alzheimer`s disease (AD) is considered a progressing neurodegenerative disease and is an important cause of aging related dementia that leads to cognitive impairment and neuronal death. AD is directly related to increased amyloid precursor protein (APP) expression and increased t [....] » Read More
The genus Bridelia is known to contain diverse secondary metabolites isolated which exhibited biological activities. The aim of this study was the isolation, in vitro, molecular docking and in silico studies of four (4) bioactive phenolic compounds with a potential anti-depressiv [....] » Read More
The "leaky pipeline" is a well-documented phenomenon in the field of neuroscience, illustrating the attrition of female talent at various stages of their careers. Despite substantial gains in recent years, women continue to encounter unique and systemic challenges that [....] » Read More
Introduction: Personality disorders are common in the general population and are a major concern for hospital clinicians, given their comorbidity with other psychiatric and addictive disorders. The aims of our study were to describe the sociodemographic, clinical, and therapeutic [....] » Read More
Background: Multiple sclerosis (MS) is an abnormal immune-mediated response that results in damage within the central nervous system causing physical limitations, cognitive changes, and psychological distress. With the advent of disease-modifying therapy (DMT), patients can exper [....] » Read More
Introduction: Swallowing is a fundamental physiological process for individual health and survival. The cerebellum has an integral function in regulating motor control and coordination; however, its specific role in swallowing physiology remains poorly characterized in humans. Th [....] » Read More
Primrose syndrome is a rare autosomal dominant disorder with less than 1000 reported cases in the United States. All reported probands show de novo ZBTB20 pathogenic variant and are characterized by recognizable facial phenotype, macrocephaly with developmental delay, sensor [....] » Read More
Objective: Raise awareness of medication induced toxic myopathy. Background: Myopathy encompasses increase of creatine kinase, myalgia, muscle weakness, rhabdomyolysis. Statins and colchicine carry a risk of myopathy. The mechanism of statin-induced myopathy is i [....] » Read More
The dopamine measurement in human blood or urine could be an valuable index in the neuropsychiatric disorders. Dopamine belongs to a class of analytes for biosensors, known as neurotransmitters from the catecholamine family. Neurotransmitters have implications in brain functions, [....] » Read More
Introduction: Data on the genetic heterogeneity of autoimmune diseases of the nervous system, among which the most common is multiple sclerosis (MS), stimulate many studies to search for links between individual gene polymorphisms and the risk of developing diseases, their c [....] » Read More
In India, a considerable portion of the population is affected by mental illnesses due to inadequate coverage of mental health care. Psychiatric disorders pose increasing challenges from both sociological and economic standpoints. Physicians confront difficulties in opt [....] » Read More
Special attention is directed towards understanding the mechanisms underlying the development of multiple sclerosis, with a particular focus on humoral immune factors, including cytokines and circulating immune complexes (CICs). These factors play a pivotal role in the processes [....] » Read More
Background: Female sex is a known risk factor for long-COVID. With the increasing number of COVID-19 cases, the corresponding number of survivors is also expected to rise. To the best of our knowledge, no systematic review has specifically addressed the gender differences in [....] » Read More
Background: Individuals suffering from long-COVID can present with “brain fog” characterized by a range of cognitive impairments such as confusion, short-term memory loss, and difficulty concentrating. To date, several potential interventions for brain fog have b [....] » Read More
Objective: This review aims to explore the effects of personalized care and early rehabilitation on patients with intracerebral hemorrhage and how these approaches improve patient survival rates and functional outcomes. Methods and Materials: The literature review primarily reli [....] » Read More
Background: On the basis of conventional treatment, explore the clinical efficacy of acupuncture calming the mind on the functional impact of patients with post-stroke depression (PSD). Methods: Select hospitalized PSD patients treated in our hospital from January 2019 to Dece [....] » Read More
Background: Obstructive sleep apnea syndrome (OSAS) and atrial fibrillation (AF) has been previously linked to elevated risk of ischemic strokes. However, the additive impact of both OSAS and AF on the long-term outcomes of patients with ischemic stroke remains largely unknown. [....] » Read More
Title : Highlights of the adverse effects of popular 'Whole body vibration' machines on the central and peripheral nervous systems
Ken Ware, NeuroPhysics Therapy Institute, Australia
Whole body vibration (WBV) involves using machines or platforms to transmit periodic pulse/wave energy to the body, causing muscles to contract and relax passively. While scientific evidence on the noxious effects of popular WBV machines is limited, experts generally agree that l [....] » Read More
Title : Novel signaling mechanisms and therapeutic options for diabetic vascular dementia
Yong Xiao Wang, Albany Medical College, United States
Vascular dementia is a neurodegenerative disease. This disease is also known as vascular contributions to cognitive impairment and dementia (VCID). As well documented, VCID has high morbidity and mortality, and diabetes is a leading factor in the development of VCID. However, the [....] » Read More
Title : Turning research into action - Cogs Club
Jaqueline Tuppen, Cogs Club, United Kingdom
The NICE guidelines in November 2006 stated: "People with mild / moderate dementia of all types should be given the opportunity to participate in a structured group cognitive stimulation programme. This should be commissioned and provided by a range of health and social [....] » Read More
Title : Antibody-proteases as the upgraded translational tools of the next-step generation in personalized and precision neurology practice to monitor multiple sclerosis at clinical and subclinical stages
Sergey Suchkov, The Russian University of Medicine and The Russian Academy of Natural Sciences, Russian Federation
Biomarkers enable pre-early diagnosis, guide targeted therapy and monitor the active ty and therapeutic responses across the diseases. Among the best-validated predictive biomarkers are autoimmunity-related ones to predict and prognosticate risks of the chronification, complicati [....] » Read More
Title : Development of the early diagnosis of parkinson’s disease at the prodromal stage
Michael Ugrumov, Institute of Developmental Biology RAS, Russian Federation
Parkinson’s disease (PD) is diagnosed many years after its onset, under a significant degradation of the nigrostriatal dopaminergic system, responsible for the regulation of motor function. This explains rather low effectiveness of the treatment of patients. Therefore, one [....] » Read More
Title : Genetic and cytokine influences on cognitive recovery following traumatic brain injury: A longitudinal study
Emily R Rosario, Casa Colina Hospital and Centers for Healthcare, United States
Objectives: This study aimed to investigate the relationship between APOE genotype, cytokine levels, and cognitive outcomes in patients recovering from traumatic brain injury (TBI). The objectives were to assess the impact of APOE ε2 and ε4 variants on cytoki [....] » Read More
Title : Recent advances in brain imaging
Mohit Saxena, Northwestern University Feinberg School of Medicine, United States
Introduction: Brain surgery may benefit from functional MRI (fMRI) that can detect changes in cerebral blood flow and oxygen utilization caused by tissue activation. Therefore, the patient needs to perform certain tasks in the scanner while fMRI is acquired. However, task-ba [....] » Read More
Title : Alzheimer’s disease and healthy aging indicators cognitive decline
Hamna Khuld, Columbia University, United States
Background: In the United States (U.S.) and Puerto Rico, cognitive decline and resulting Alzheimer's disease are major public health concerns for older adults. According to the Alzheimer's Association (2021), by 2050, people ages 65 and above with Alzheimer's are esti [....] » Read More
Title : CrataBL, unraveling glycosaminoglycan-mediated pathophysiological processes in disease progression and facilitating drug discovery for sulfotransferases
Rodrigo Da Silva Ferreira, University of Brasília, Brazil
Tumour angiogenesis is a crucial process for the growth of cancerous cells, involving the formation of new blood vessels and being heavily influenced by sulfotransferase enzymes (1). These enzymes play a central role in modifying glycosaminoglycans in the extracellular matrix and [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model to be set up to secure the human healthcare, wellness and biosafety through the view of public health
Sergey Suchkov, The Russian University of Medicine and The Russian Academy of Natural Sciences, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). To achieve the implementation of PPM concept, it is necessary to create a fundamentally new strategy based upon the recogni [....] » Read More
Title : Antigravity suit "Atlant" in neurological rehabilitation of patients with motor and cognitive impairments
Valida Isanova, Kazan State Medical University, Russian Federation
The nervous system disorders and mental impairments still remain to be among the main causes of children and adults incapacity. Currently neurorehabilitation has a particular relevance and importance among people suffering from nervous system disorders, incapable of moving i [....] » Read More
Title : A wide variety of neurologic manifestations in the antiphospholipid syndrome
Ljudmila Stojanovich, University Medical Center, Serbia
Objectives: Aim of this study was to investigate association between neurological with manifestations and antiphospholipid antibodies type and level in APS patients. Methods: Our prospective study comprises of 333 patients: 218 with primary and 115 with secondary APS. Antiphosph [....] » Read More
Title : Exploring the enablers and barriers to implementing evidence-based practice in acute stroke care
Kelsey Bonnici, University of Malta, Malta
The integration of evidence-based practises (EBPs) plays a crucial role in enhancing patient outcomes and lessening the impact of post-stroke disability, particularly in the realm of acute stroke care within the healthcare field. The objective of this study is to explore the vari [....] » Read More
Title : A case report of full term newborn with large intracranial hemorrhage surviving complex interventions of craniectomy and acute peritoneal dialysis in the neonatal period
Karen Obillo Calibuso, Armed Forces of the Philippines Victoriano Luna Medical Center, Philippines
This is an interesting case of a Full-term 38 weeks newborn, 2950 grams, born with meconium- stained amniotic fluid indicative of intrauterine fetal distress which resulted in complex conditions requiring interventions rarely done in newborns in our set-up. Further, the patient p [....] » Read More
Title : EEG application pre-and post-cerebral cortex disconnection surgery in intractable epilepsy
Shuhua Chen, Capital Medical University, China
Cerebral cortex disconnection surgery is a surgical treatment method for drug-resistant epilepsy patients. By this surgical technique,the connection between the epileptic cerebral tissue and its related structures and adjacent brain tissue were disconnected completely. It means t [....] » Read More
Title : Quantitative evaluation of factors contributing to the results of 3hz RNS test on ALS patients
Jinghong Zhang, Beijing 301 Hospital, China
Introduction: Previous studies have suggested that therapeutic treatments aimed at preserving neuromuscular junction (NMJ) may play an imperative role in fighting against amyotrophic lateral sclerosis (ALS). However, as far as repetitive nerve stimulation (RNS) test, a technique [....] » Read More
Title : Pioneer transcription factor Runx2 affecting biological function of schwann cells via self-inducible reconstruction of silencer to remodel chromotin
Zhaowei Zhu, The Third Affiliated Hospital of Sun Yat-sen University, China
The repair and regeneration of injured peripheral nerves is a difficult problem in modern medicine. In the current experiment, we found that the expression of Runx2 in Schwann cells (SCs) increased significantly in the early stage of injury after injury, and single-cell sequencin [....] » Read More
Title : The brain mechanism regulating mammalian reproduction
Hiroko Tsukamura, Nagoya University, Japan
Accumulating evidence suggests that hypothalamic kisspeptin neurons are the master regulator for mammalian reproduction to govern the hypothalamus-pituitary-gonadal (HPG) axis. Indeed, mutation or deletion of kisspeptin gene (Kiss1) or its receptor gene (GPR54) causes hypog [....] » Read More
Title : Upside down words as initial clinical presentation of an underlying acute ischemic stroke
Ramuel Spirituel Mattathiah A San Juan, Baguio General Hospital and Medical Center, Philippines
Background: Reversal of vision metamorphopsia is a transient form of metamorphopsia described as an upside-down alteration of the visual field in the coronal plane. Patients would describe objects, such as cups, upside down but the tea would not spill; and people would walk on th [....] » Read More
Title : Case report and literature review of opalski syndrome: A rare brainstem stroke
Ramuel Spirituel Mattathiah A San Juan, Baguio General Hospital and Medical Center, Philippines
Background: Infarcts in the lateral medulla do not present with hemiparesis because of the different vascular supply for the corticospinal tract, located in the tegmentum of the medulla. If an infarct of the medulla has hemiparesis, it would be from a medial medullary stroke, and [....] » Read More
Title : In vitro investigation of neuroprotective effects: Unveiling the impact of Aβ25-35-induced oxidative stress on SH-SY5Y cells and the therapeutic potential of phytochemicals
Harkomal Verma, Central University of Punjab, India
Alzheimer’s disease (AD) is intricately linked to oxidative stress induced by the accumulation of amyloid beta (Aβ) peptide, disrupting cellular functionality. This comprehensive study investigates the multifaceted impacts of Aβ25-35-induced oxidative stress on hu [....] » Read More
Title : Role of care homes & assisted living facilities in caring for people with neurological disorders
Veronicah Akankunda, Golden Age Elderly Homes Kampala, Uganda
Introduction: Dementia is an age mental disorder that makes victims lose normal functionality that need delicate attention. It has been technically defined as a clinical syndrome characterised by a cluster of symptoms manifested by difficulties in memory, disturbances in spe [....] » Read More
Title : A novel deletion variant in CLN3 with highly variable expressivity is responsible for juvenile neuronal ceroid lipofuscinoses
Naser Gilani, Farabi Medical Laboratory, Iran (Islamic Republic of)
With more than 7,000 identified rare diseases and approximately 80 % being linked to genetic causes, diagnosing rare disease patients can often be difficult – resulting in lengthy, expensive, and emotional diagnostic odysseys, but with revolutionary advances in Molecular [....] » Read More
Title : The efficacy of powered gait orthoses on walking in persons with spinal cord injury: A literature review
Zeinab Gasavi Nezhad, University of Social Welfare and Rehabilitation Science, Iran (Islamic Republic of)
Background: Powered gait orthoses are a new group of assistive devices used to rehabilitate people with spinal cord injuries. These orthoses create movement in the joints and lower limbs of spinal cord injury patients through external power caused by electric motors, pneumatic or [....] » Read More
Title : Impact of neuron with two dendrites in heart behavior
Kaouther Selmi, University of Monastir, Tunisia
Neurons are the fundamental units of the brain and the nervous system. The variable structure model of neurons is a system of differential equations with various parameters. By optimizing these parameters, we can create a unique model that describes the dynamic behavior of a sing [....] » Read More
Title : Pontine toxoplasmosis in an immunocompromised filipino male: A case report
Michelangelo Liban, Baguio General Hospital and Medical Center, Philippines
A 36-year-old-male was admitted complaining of headache, right sided weakness and numbness of upper and lower extremity, and multiple cranial nerve deficits. Cranial magnetic resonance imaging revealed an abscess in the pontomesencephalic junction. Patient was then di [....] » Read More
Title : Diabetic striatopathy as an initial presentation of type 2 diabetes mellitus in an 80 year old Filipina: A case report
Michelangelo Liban, Baguio General Hospital and Medical Center, Philippines
A case of a 93 year old Filipina who experienced a sudden onset of left sided hemichoreahemiballismus after falling from a standing height due to dizziness. She was not known to have Diabetes Mellitus nor experienced any symptoms of diabetes aside from its rare neurological manif [....] » Read More
Title : Sodium danshensu from radix and rhizoma salvia miltiorrhiza exerts neuroprotection against ischemia and reperfusion injury through the inhibition of ferroptosis mediated by the Nrf2/SLC7A11/GPX4 axis
Chao Guo, Fourth Military Medical University, China
Background: Ferroptosis, as iron-dependent, exerts a vital role in the pathogenesis and progression of ischemic stroke. Nuclear factor-E2-related factor 2 (Nrf2) can positively regulate the transcription of Recombinant Solute Carrier Family 7, member 11(SLC7A11) and glutathione p [....] » Read More
Title : Post-dural puncture headache treated with greater occipital nerve block
Milton C R Medeiros, Irmandade Santa Casa de Arapongas PR, Brazil
Post-dural puncture headache (PDPH) is an important and relatively frequent complication after spinal anesthesia. It is intense pain that worsens when sitting or standing and improves when lying down. Epidural blood tamponade is the most effective treatment, but it is invasive. - [....] » Read More
Title : Towards brain-computer interface based communication tool utilizing EEG signals integrated with large language model
Hyeong Yeong Park, Chungbuk National University, Korea, Republic of
Brain-computer interface (BCI) is a research field that involves analyzing and classifying signals from brain activity using machine learning or deep learning and applying them to various applications. Speech imagery decoding involves analyzing brain waves induced by the user&rsq [....] » Read More
Title : The use of gabapentin in the management of dysautonomia in neurologic disorders: A systematic review
Jane Marice S Pascual, Philippine General Hospital, Philippines
Background: Dysautonomia can be seen in some neurologic conditions and is known to increase morbidity if not treated accordingly. It has been poorly addressed in neurological conditions and its debilitating effects may even lead to mortality. Addressing it may lead to improvement [....] » Read More
Title : Refractory anti-NMDAR encephalitis with multiple nosocominal infections: Paradigm shift required in the therapeutical options.
Sachin G Nair, Amrita Institute of Medical Sciences & Research Center, India
Background: With no randomised controlled trials or consensus guidelines for the treatment of anti-NMDAR encephalitis, the heterogeneity in the treatment stratagem has not yet reported any evidence on the therapeutic option of choice when infections ensue during the immunosuppres [....] » Read More
Title : Implementing technology for schizophrenia and psychotic diseases: Differentiating hallucinations from reality
Shreya Bhoj, DIT University, India
This research aims at providing an overview of schizophrenia and psychotic disorders, elucidating the complex interplay between neurobiological, environmental, and psychological factors contributing to hallucinations and reality distortion. Additionally, it explores the phenome [....] » Read More
Title : Tailored care homes for neurological disorders: A person-centered approach
Rwakiseta Herbert, Golden Age Elderly Homes Kampala, Uganda
This presentation, titled "Tailored Care homes for Neurological Disorders: A Person-Centered Approach," delves into the critical role of care homes and assisted living facilities in developing and implementing individualized care plans for residents with neurological di [....] » Read More
Title : Validation of instadx, a clinical decision support tool information technology based application for ischemic stroke sub-type diagnosis
Saadia Sattar, Aga Khan University, Pakistan
Globally ischemic stroke is the second leading cause of mortality and morbidity among the adult population. Prompt diagnosis of ischemic stroke sub-type can lead to better clinical outcomes. This study aimed to adapt and develop mHealth-based android application ‘InstaDx&rs [....] » Read More
Title : Computer-aided detection and classification of ischemic strokes from MRI images in LMIC– A retrospective cohort study
Saadia Sattar, Aga Khan University, Pakistan
Ischemic stroke is a leading cause of morbidity and mortality globally. The high interfacing ratio of patients to professionals in Pakistan’s population is a great hindrance to access to care. This study intends to develop a computer-aided detection and classification syste [....] » Read More
Title : Thoracic sulcal artery infarct presenting as brown-sequard syndrome
Loo Shweh Fern, National Neuroscience Institute, Singapore
Introduction: Thoracic spinal cord infarct is a rare but severe disorder that constitute 1-2% of neurological vascular emergencies. The severity, disease trajectory, progression and recovery rate remains a puzzle in view of its varies presentation and rarity. Meth [....] » Read More
Title : Prevalence of undiagnosed risk factors in patients with first ever ischemic stroke treated at MUHC
Shorog Althubait, King Khalid University, Saudi Arabia
Introduction: Undiagnosed risk factors (URF) defined as risk factors newly diagnosed during inpatient evaluation for stroke are a missed opportunity for primary stroke prevention; we sought to determine the prevalence of URF among first ever ischemic stroke (IS) cases seen at MUH [....] » Read More
Title : Zinc deficiency: A harbinger of vestibular dysfunction?
Madhusudhan Umesh, AIIMS, India
Background: Role of zinc in the maintenance of redox homeostasis have been explored & is established to have antioxidant effects in the body. Presence of zinc in auditory system & its role in deafness & tinnitus is well established. Zinc supplementation has shown to n [....] » Read More
Title : Investigating the efficacy of neurofeedback via EEG to improve cognition
Shaina Mohite, DIT University, India
Cognitive function plays a crucial role in daily life. Traditional methods for enhancing cognition requires dedicated practice and can be challenging to maintain. This research explores the potential of Electroencephalography (EEG) technology, specifically neurofeedback, as a too [....] » Read More