a-Synuclein (aSyn) aggregation is a key factor in neurodegeneration in Parkinson’s disease (PD). We have used the different structural properties of toxic oligomers and amyloid fibrils to identify a family of peptides that bind to these a-synuclein species with low nanomola [....] » Read More
The recent explosion of biomarker science in Alzheimer’s disease and brain aging has led to novel therapies finally reaching patients. However, the utility of these advancements to diverse populations remains largely unknown due to lack of inclusion of these populations in [....] » Read More
Definition and Types: TBI is an injury to the brain caused by external force, resulting in a range of effects. It can be classified as mild (concussions), moderate, or severe based on symptoms and impact. Causes: Common causes include falls, vehicle accidents, sports in [....] » Read More
Neurodegenerative diseases (Parkinson and Alzheimer’s diseases) represent a pandemic that affects millions of humans around the globe, and for which there is no cure or effective treatments or medications. The gut microbiota, the trillions of microorganisms inhabiting the i [....] » Read More
Aims: Upper limb paresis, which includes disorders of extension and wrist control, is one of the most common and debilitating complications after a stroke. It significantly impacts patients' independence. Conventional rehabilitation methods do not always effectively impr [....] » Read More
Background: Cognitive symptoms are among the most common reasons patients seek neurological care, yet cognition is often assessed inconsistently in routine clinical practice. As neurological disorders increasingly affect aging populations worldwide, early identification of cognit [....] » Read More
This presentation proposes a theoretical model positioning the inner ear – particularly the vestibular system – as a key contributor to neural synchronisation processes and cognitive network regulation. Traditionally viewed through its role in balance and spatial orie [....] » Read More
Background: Chronic migraine is a disabling and often treatment-resistant neurological disorder. Transcranial Direct Current Stimulation (tDCS) is a non-invasive neuromodulation technique with emerging evidence for pain management. To assess the efficacy and safety of anodal tDCS [....] » Read More
Introduction- Transverse Myelitis is characterized by abrupt onset progressive weakness with sensory disturbances. Pathogenesis is usually implicated with direct viral invasion or vasculitis or an autoimmune response. TM Plus syndrome is association with another neuroinflam [....] » Read More
Introduction: The concept of reconstruction post-traumatic skull defects is based on restoring anatomical relationships to maximize recovery of brain function, i.e., it is considered as a mandatory stage of surgical rehabilitation. The choice of implant, taking i [....] » Read More
One of the most important problems in modern neuroscience is determining how pharmacological substances affect brain function. There is currently no methodical way to assess these effects in whole-brain models, which usually concentrate on macroscopic phenomena, whereas pharmaceu [....] » Read More
Postpartum Depression (PPD) is a complex neuropsychiatric disorder frequently precipitated by chronic stress, with its pathophysiology involving the kynurenine pathway, neuroinflammation, and oxidative stress. Conventional antidepressants often exhibit limited efficacy and are as [....] » Read More
Nuclear Factor-Kappa B (NF-κB) is a key regulator of inflammation and apoptosis implicated in the pathogenesis of Autism Spectrum Disorder (ASD). Aberrant NF-κB activation has been observed in the brain, particularly in microglia, and peripheral blood of individuals w [....] » Read More
Neuromorphic Collective Intelligence System for Enhanced Neurological Diagnostic Accuracy. Background: Traditional neurological diagnosis relies heavily on individual clinician expertise, leading to significant variability in diagnostic accuracy across institutions and special [....] » Read More
Background: Autism Spectrum Disorders (ASD) are a series of neurodevelopmental disorders characterized by social disorders, rigid behaviors and narrow interests. The World Health Organization (WHO) estimates that the prevalence of ASD has been increasing over the past 50 years. W [....] » Read More
Health and social care systems around the globe currently undergo a transformation towards personalized, preventive, predictive, participative precision medicine (5PM), supported by technology. It considers individual health status, conditions, genetic and genomic dispositions in [....] » Read More
The presentation starts with coverage of Advanced Neuroimaging and Neuro Technologies. Next, there will be an introduction to Behavioural Neuroscience, Gut-brain-axis, Microbiome, computational neuroscience and neurology. The discussion will the move on to dissecting concepts lik [....] » Read More
Prior to WWII the majority patients with tSCI died in hospitals. There was however no shortage of Clinicians experimenting with the management of the injured spine. During WWII L. Guttmann (a well-trained aggressive Neurosurgeon) was given the task of looking after injured soldi [....] » Read More
Introduction: Early diagnosis of patients with Mild Cognitive Impairment (MCI) is essential to initiate early treatments that may slow their progression towards dementia. Because accurate biological and imaging markers are not accessible to all healthcare systems, neuropsychologi [....] » Read More
Background: Emerging neuroscience demonstrates that the brain is capable of rapid, sub‑second shifts in cognition, affect, and behavioral intention. Research across decision neuroscience, dopaminergic signaling, and neuroplasticity shows that micro‑moment interventions c [....] » Read More
Patients with Functional Seizures (FS) (also known as Psychogenic Non-Epileptic Seizures (PNES), have involuntary paroxysmal episodes that resemble epileptic seizures but without organic etiology. Many patients with FS have a history of sexual, physical, or emotional abuse, or ot [....] » Read More
It has been noted by multiple researchers that there is Spontaneous Electrical Activity (SEA) at painful trigger points. This author has studied chronic muscle spasm and found that SEA is always present and appears to be the cause for the chronic nature of muscle spasm and result [....] » Read More
Epigenetics is the study of how cells control gene activity without changing the DNA sequence. Epigenetic changes affect how genes are turned on and off, or expressed, and thus help regulate how cells in different parts of the body use the same genetic code. Errors in [....] » Read More
Objective: To investigate the effect of and Acupuncture on brain plasticity and motor development in children with cerebral palsy. Investigate effect on mechanism of apoptosis of brain nerve cells, regulating the expression of neurotrophic factors, promoting the remodeling of ner [....] » Read More
Background: Mild traumatic brain injury (mTBI) is common, with subtle symptoms and long-term consequences, but the brain network remodeling and its link to behavioral disorders remain unclear. Ultrashort wave (USW) therapy, a potential non-invasive treatment, has not been systema [....] » Read More
Cerebral ischemic preconditioning (CIP), a phenomenon in which a brief, sub-lethal ischemic episode confers robust protection against a subsequent severe stroke, is a powerful intrinsic mechanism for enhancing brain ischemic tolerance. Ferroptosis is now recognized as a critical [....] » Read More
Diquat (DQ) is a widely used new herbicide that poses a great threat to the environment, ecological systems and human health. Although the Central Nervous System (CNS) is a sensitive target of DQ exposure, the major brain regions, pathological changes and underlying mechanisms of [....] » Read More
Growth Differentiation Factor 15 (GDF15) is a well-recognized neurotrophic and regulatory factor. Serum levels of GDF15 are an independent risk factor for stroke and an effective predictor of ischemic stroke outcomes. Currently, there is a lack of research on the mechanism of GDF [....] » Read More
As a plant flavonoid compound, chrysin comes from Scutellaria Baicalensis Georgi (Huangqin), which has a powerful immunoprotective effect to suppress immune inflammatory responses, and plays an outstanding role in the treatment of various brain diseases. This study aims to explor [....] » Read More
Aim/Background: To study prevalence and outcomes associated with clinico-socio-demographic factors in treated NTICH (non-traumatic intra-cranial hemorrhage) patients in Institute Of Human Behaviour And Allied Sciences (IHBAS). Materials and Methods: Study Population: All ne [....] » Read More
Brain-Computer Interfaces are on a cross road with BCIs quickly moving out of the research avenues to clinical use and consumer applications with more than 400 ongoing clinical studies around the world and market estimates of more than $5 billion in the next decade. However, as t [....] » Read More
Acquired brain injuries (ABIs), including stroke and traumatic brain injuries (TBIs), frequently result in visual system impairments ranging from basic sensory deficits to complex perceptual dysfunctions, significantly affecting independence, safety, and quality of life. This nar [....] » Read More
Type 2 diabetes is associated with the formation of features of Alzheimer’s disease (AD). A common mechanism appears to be the impairment of autophagy, making its stimulation a potential target for AD treatment. A good opportunity to study the correction of diabetes and neu [....] » Read More
Epilepsy affects 50 million people worldwide and has a significant influence on their quality of life. Epilepsy prevalence varies depending on a variety of conditions, although it is more frequent in underdeveloped countries. This underscores the crucial need for advances in trea [....] » Read More
Vascular Dementia (VaD), a major contributor to cognitive decline, arises primarily from impaired regulation of cerebral circulation. Pterostilbene (PTE), a natural stilbene, exhibits potent neuroprotective properties, including antioxidative, anti-apoptotic, and cognition-enhanc [....] » Read More
Anemia is an iron deficiency that often results in the decrease of Red Blood Cells (RBC). One of the worldwide public health issues affecting children and pregnant women is anemia. The main cause of anemia is increased RBC destruction, blood loss, and defective cell production. I [....] » Read More
Machine learning and Brain–Computer Interface (BCI) technologies are converging to create transformative possibilities in neuroscience, medicine, and human–machine interaction. BCIs enable direct communication between the brain and external devices by decoding neural [....] » Read More
Brain cancer and its treatments bring a unique threat to the patient’s identity and quality of life by challenging their essential identity in significant ways, possibly including impaired cognitive skills, loss of memory, reduced coordination, altered feeling states, and l [....] » Read More
Background: Female glioblastoma (GBM) patients consistently outlive males by 3 to 5 months even after controlling for age, surgical extent, and MGMT methylation status. The biological mechanism driving this survival gap remains unresolved. Nearly all existing research examin [....] » Read More
Parkinson’s Disease (PD) is a progressive Parkinson's disease characterized by degeneration of dopaminergic neurons in the substantia nigra, resulting in motor dysfunction, cognitive decline, and substantial long-term socioeconomic burden. Despite advances in symptomati [....] » Read More
Chronic pain is defined as persistent pain lasting more than three months, resulting in alterations in the brain's functional synaptic network and its gray matter dimensions. It causes hypersensitivity to nociceptive stimuli and increased excitability of the nodal stress mec [....] » Read More
Scientists have expanded the notion of the brain plasticity. If necessary, even specialized motor neurons can be taught to perform functions completely alien to them.Neurophysiologists from the University of California, Berkeley (USA) described an experiment in which the rat neur [....] » Read More
Background: Extracranial cervical artery dissection is a significant cause of stroke in young patients without traditional cardiovascular risk factors; however, its clinical presentation is often nonspecific, which may delay timely diagnosis. This paper presents a clinical c [....] » Read More
Background: Language is left-hemisphere dominant in approximately 90–95% of right-handed individuals (1–3). As a result, it is often assumed that left-frontal gliomas in right-handed patients involve critical language areas and are therefore not safe for surgical [....] » Read More
Objective: Delayed cerebral ischemia (DCI) caused by cerebral vasospasm remains a major cause of morbidity after aneurysmal subarachnoid hemorrhage (aSAH). Intra-arterial nimodipine (IAN) is increasingly used as rescue therapy in patients with vasospasm refractory to induced hype [....] » Read More
Introduction. In Eastern martial arts, non-contact mental influence on a partner is described, often associated with the concept of "energy-informational exchange." The Kyokushin Karate Kata (KKK) practice is particularly noteworthy in this context. Objective. To explo [....] » Read More
Adaptive behavior depends not only on learning from rewards, but also on the brain’s capacity to respond when expected rewards fail to occur. Reward omission is a powerful trigger of negative emotional states such as frustration and anxiety and is increasingly recognized as [....] » Read More
Advances in high‑resolution genomic technologies—including chromosomal microarray, next‑generation sequencing, and targeted CNV assays—have substantially enhanced our ability to detect clinically meaningful structural variation in patients with suspected neurodeve [....] » Read More
Introduction: Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection caused by reactivation of the John Cunningham (JC) virus in immunocompromised patients and may present with focal neurological deficits that mimic stroke. Case Presentation: We repor [....] » Read More
Title : Perception and individuality in patient cases identifying the ongoing evolution of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Ken Ware, NeuroPhysics Therapy, Australia
The way individuals perceive and interpret their internal and external environments directly influences how they function and adapt within them. In a stable and well-regulated human system, perception tends to align closely with reality, allowing for accurate motor responses and [....] » Read More
Title : Rabies: Challenges in taming the beast
Alan C Jackson, University of Calgary, Canada
Rabies has occurred in humans and animals since antiquity and remains an important public health problem with about 60,000 human deaths per year, particularly in Asia and Africa. The disease is virtually always fatal, although at least 34 survivors have been documented; unfortuna [....] » Read More
Title : When Dementia strikes early: The implications for family and services
Jaqueline Tuppen, COGS Club, United Kingdom
Addressing the social determinants of health, including poverty, education, and access to healthcare, is critical in reducing the impact of public health crises and ensuring better health outcomes for all. This presentation will share the worldwide impact of people and families [....] » Read More
Title : Personalized and Precision Medicine (PPM), as a unique healthcare model through biodesign-driven biotech and biopharma, translational applications, and neurology-related biomarketing to secure human healthcare and biosafety
Sergey Victorovich Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Over the course of history, healthcare and thus healthcare philosophy have been focused predominantly on efforts to probe the already diseased individual by focusing down on a type of disorder (nosology) rather than on health or so-called pre-illness conditions. Much less effort [....] » Read More
Title : Antibody-proteases as translational tools of the next-step generation to be applied through biodesign-driven translational biotech in personalized and precision neurology practice
Sergey Victorovich Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Multiple Sclerosis (MS) is a complex neurodegenerative pathology featuring with inflamma-tion, demyelination, and neurodegeneration. Due to the heterogeneity of MS-related clinical and even subclinical subtypes, their diagnosis becomes challenging and the best treatment cannot be [....] » Read More
Title : Resolution of the CSF-SBP phase paradox: A mathematical framework for cerebral pressure dynamics
Mustafa A Khan, Sevaro Health Inc., United States
Objective: To resolve the clinical paradox where CSF pressure peaks before systolic blood pressure yet both drop to zero simultaneously during cardiac arrest. Backgroud: CSF pressure demonstrates 50-100ms phase lead over systolic blood pressure during normal cardiac cycles, yet [....] » Read More
Title : Effects of multimodal therapy on psychological symptoms in Huntington’s disease
Andrea Dincher, Saarland University, Germany
Introduction: Huntington's Disease is a hereditary neurological disorder that is currently incurable. Only the symptoms can be treated, often with multimodal therapy. Some studies suggest that such a multimodal therapy can improve psychological symptoms in Huntington’s [....] » Read More
Title : Mathematical proof reveals Cushing’s triad as diastolic collapse: The 2:1 ratio as a precision diagnostic marker and novel therapeutic target
Mustafa A Khan, Sevaro Health Inc., United States
Objective: To derive the precise hemodynamic mechanism of Cushing’s triad using fundamental physics principles and validate quantitative predictions against clinical data. Background: Cushing’s triad has been misunderstood as protective hypertension for over a centur [....] » Read More
Title : Study of resilience in cases of incest, father-daughter, step-father and step-daughter in the pre-pubber and puberous period among adult women and mothers: How to overcome the traumatisms of an incestuous relationship?
Daniele Lapointe, Laval University, Canada
Sexual abuse of a child is a form of maltreatment. Among recent studies in this area, the Canadian study (Burczycka and Conroy, 2017) indicates that 70.3% are intrafamilial abuse and that of all cases of sexual abuse, 81% of victims are female (Silva and Collin-Vézina, 201 [....] » Read More
Title : Spasticity management and the use of radial shock waves in post-stroke patients
Klaudia Marek, Department of Neurological Rehabilitation, Medical University of Lodz, Poland
Aims: Recent studies predict that the number of people diagnosed with stroke in the European Union will rise by 27% by 2047, driven by an aging population and improved survival rates. One of the most common complications following stroke is upper limb spasticity. As spastici [....] » Read More
Title : Neuroprotective, anticonvulsant, and proconvulsant effects of cannabinoids following neurotrauma
Linda K Friedman, NeuroInfusions LLC, United States
Traumatic brain (TBI) injuries result in profound local hypoperfusion, ischemia, chronic inflammation and refractory seizures (post-traumatic epilepsy (PTE) and restrict drug delivery to the site of impact so that peripheral treatment alone would have limited access to the site o [....] » Read More
Title : Neuroprotective potential of a traditional Uttarakhand plant against lambda-cyhalothrin-induced neural impairment: A pharmacological investigation
Mandeep Kumar Arora, Department of Pharmacy, DIT University, India
Neurodegenerative disorders are a group of diseases characterized by the progressive loss of structure or function of neurons, including brain cells, leading to impaired movement, cognition, and other neurological functions. Several factors contribute to the progression of neurod [....] » Read More
Title : Nutrition and neurodegeneration: The role of dietary interventions in Alzheimer’s disease
Sara Adel Ahmed, Ain Shams University, Egypt
Chronic inflammation plays a critical role in most of challenging diseases, including rheumatoid arthritis, cancer, heart disease, diabetes, asthma, and even neurological diseases such as Alzheimer’s and depression. Many studies proved how different dietary components can m [....] » Read More
Title : Case report: Neuroimaging changes of nonketotic hyperglycemia chorea patient with status epilepticus attack
Hyung Jin Lee, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Korea, Republic of
Background: We present the neuroimaging findings of case of non-ketotic hyperglycemia (NKH) associated with seizures and chorea. Seizures of NKH patients are usually focal motor seizures, rarely progress to status epilepticus with secondary generalization. Case Presentatio [....] » Read More
Title : The role of interleukin 6 in ischemic stroke
Hanna Pawluk, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
Ischemic stroke is one of the leading causes of mortality and long-term disability worldwide, resulting from the sudden occlusion of a cerebral vessel and subsequent hypoxia of neural tissue. This event triggers a complex pathophysiological cascade involving excitotoxicity, oxida [....] » Read More
Title : The role of TNF-α in ischemic stroke
Renata Kolodziejska, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
Ischemic stroke is one of the leading causes of mortality and long-term disability worldwide. Its pathogenesis is associated with the sudden occlusion of a cerebral artery, resulting in a critical reduction of blood flow and oxygen supply to brain tissue. This triggers a complex [....] » Read More