Resting state fMRI is a non-invasive functional imaging method used to assess brain activity in un-stimulated conditions. It is based on the principle that changes in the magnetic properties of oxygenated blood can be used to measure activity in the brain. The technique has been used in various research and clinical studies to investigate the behavior of the brain in resting state. Resting state fMRI can be used to assess the functional connectivity of the brain, that is the communication between different brain areas. It works by measuring patterns of brain activity that are present even in the absence of any external stimuli. This allows researchers to gain a better understanding of the functioning of the entire brain. Using this technique, researchers have been able to identify patterns of functional connectivity such as resting-state networks, which are associated with specific cognitive abilities and pathology. Resting state fMRI is based on the principle of blood oxygen-level dependent (BOLD) contrast. This principle states that changes in the concentration of oxygenated hemoglobin in the brain are closely related to changes in brain activity. The BOLD contrast is measured by detecting changes in the magnetic properties of oxygenated blood. These changes are used to construct an image of the brain that reveals the patterns of brain activity. One of the advantages of resting state fMRI is that it does not require any complicated task or external stimulation. This makes it easier to use than other functional imaging modalities such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). It also allows for longer scans, which can provide more accurate readings of brain activity. However, resting state fMRI does have some limitations such as its inability to provide detailed information about the neuronal structure of the brain. In summary, resting state fMRI is a non-invasive functional imaging technique used to assess brain activity in un-stimulated conditions. The technique is based on the principle of BOLD contrast and provides a way to measure Patterns of brain activity even in the absence of external stimuli. It has been used in various research and clinical studies to gain insights into the functioning of the entire brain.
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