Proteins are macromolecules composed of amino acids linked by peptide bonds. They are central components of all living cells and play essential roles in many biological processes, such as metabolism, cell signaling, and DNA replication. Proteins are very large molecules and their structure and function is determined by their amino acid composition. The amide group of an amino acid is hydrophilic, attracting water molecules to the protein surface. This hydrophilic nature of proteins is key for the formation of structures such as alpha helices and beta sheets, which bring amino acids in close proximity to each other, allowing them to interact through different forces, such as hydrogen bonds and ionic forces. Proteins can also be modified by post-translational modification (PTM) such as phosphorylation, glycosylation and proteolysis, which allow them to change their biological function in response to different environmental signals. Thus, proteins can be tailored to perform specific functions in the body that are not possible with unmodified proteins. Protein chemistry is the study of the structure, function, and biological activity of proteins
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