Inflammatory brain disorders encompass a wide range of conditions characterized by inflammation within the brain tissue. This umbrella term includes ailments like encephalitis, meningitis, and autoimmune disorders affecting the central nervous system (CNS). Encephalitis involves inflammation of the brain parenchyma, often caused by viral infections like herpes simplex virus or autoimmune reactions where the body's immune system mistakenly targets its own brain tissue. Meningitis refers to inflammation of the protective membranes surrounding the brain and spinal cord, usually triggered by bacterial or viral infections. Autoimmune inflammatory disorders of the CNS, such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), occur when the immune system attacks the myelin sheath, disrupting nerve signals and causing neurological symptoms like cognitive impairment, motor dysfunction, and sensory disturbances. Diagnosis typically involves a thorough neurological examination, imaging studies like MRI scans, and analysis of cerebrospinal fluid obtained through a lumbar puncture. Treatment approaches vary depending on the underlying cause and may include antiviral or antibiotic medications, immunosuppressive therapy, and supportive care to manage symptoms and prevent complications. Early detection and intervention are crucial for minimizing brain damage and improving outcomes for patients with inflammatory brain disorders.
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Robert B Slocum, University of Kentucky HealthCare, United States
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Title : Traumatic Spinal Cord Injuries (tSCI) - Are the radiologically based “advances” in the management of the injured spine evidence-based?
W S El Masri, Keele University, United Kingdom