Brain malformations are any structural abnormalities that occur in the brain during its development before birth. It can be caused by a variety of factors, including genetic mutations, environmental influences and viral infections. Brain malformations can lead to a variety of conditions and diseases, such as hydrocephalus, congenital brain defects, corpus callosum agenesis and neural tube defects. During brain development, an intricate and complex network of neurons, axons, and supporting cells are formed. Abnormalities in this network can lead to a brain malformation. Brain malformations can range from minor asymmetries to a complete absence of a brain structure. When a brain malformation is severe, it can cause a range of physical disabilities, including intellectual disability, motor control problems, and seizures. Genetic abnormalities are the most common cause of brain malformations, although environmental factors such as drug exposure, prenatal infection, or issues during the birthing process can also play a role. In some cases, the cause of the malformation is unknown. In order to diagnose a brain malformation, physicians will use a variety of imaging tools such as ultrasounds, CT scans, and MRIs to investigate the structure of the brain in detail. Treatment will depend on the underlying condition and can include medication, surgery, and physical or occupational therapy. By understanding the cause and potential treatments for brain malformations, physicians are able to provide better care and improved outcomes for individuals with these conditions. Research into the causes of brain malformation is ongoing, and advancements may help provide better diagnostic tools and treatments in the future.
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