Gamma-amino butyric acid (GABA) is the main inhibitory neurotransmitter in the brain and GABA-ergic transmission is shown to be of importance for regulation of mood, memory, and food intake. The progesterone metabolite allopregnanolone (Allo) is a positive GABAA receptor modulati [....] » Read More
Catalytic Abs (catAbs) are multivalent immunoglobulins (Igs) with a capacity to hydrolyze the antigenic (Ag) substrate. In this sense, proteolytic Abs (Ab-proteases) represent Abs to provide proteolytic effects. Abs against myelin basic protein/MBP with proteolytic activity ex [....] » Read More
The human brain operates in a protected environment of constant temperature and uninterrupted resources of oxygen and nutrients. However, many other vertebrates show amazing plasticity of their brain function. Their brains function with greater flexibility and provide import [....] » Read More
Nanomedicine has already revolutionized medicine. This is because nanomaterials can mimic the size of natural components of tissue to increase tissue growth, inhibit infection, and limit inflammation. The surface energy of nanomaterials can also be easily controlled to in turn me [....] » Read More
• Using metaphor with themselves or patients can give neurological and psychiatric scientists and clinicians a safe way to help understand how we cope with stress and how that can affect our experiences of neurological, physical and psychiatric illnesses. [....] » Read More
Given the complex etiopathology of neurodegenerative diseases and the limited access to vital human brain cells as suitable research platform, there is an increasing demand of innovative human-specific model systems that help elucidating the causative mechanisms of these disorder [....] » Read More
Background: Multiple sclerosis (MS) is a chronic, degenerative inflammatory disease of the central nervous system characterised by demyelination. Genetic factors have been implicated in its pathogenesis, however their association with MS remains unclear. Genetic variants in [....] » Read More
Electrochemistry/Mass Spectrometry is a pure instrumental approach that can mimic the metabolic process in humans. Metabolic reactions are mainly oxidations and reactions, thereby electrochemistry is an ideal alternative to the current in vitro and in vivo methods. Hyphenating el [....] » Read More
Background: The aim of this paper was to show the cognitive and emotional deficits noted in a patient following a stroke within the rehabilitation process. Case study: A 61-year-old female patient after a ischemic stroke with leftsided paresis and neuropsychological disorders. Re [....] » Read More
Schiffer has proposed and tested and published his novel hypothesis about the relation between the cerebral hemispheres and psychopathology. His ideas come out of his clinical observations and the split-brain studies and are combined in what he has termed dual-brain psychology (D [....] » Read More
The limited access to human neurons greatly impedes the progress of research in neurological diseases. Although animal models provide insights into disease mechanisms, significant species-dependent differences exist, and animal models only mirror the limited aspects of the pathop [....] » Read More
Background and aims: Sleep quality is a key aspect of the overall psychological health. Sleep quality can affect mental health in many aspects, causing major psychological disorders, such as: depression and anxiety. Objectives: to assess the overall psycholog [....] » Read More
Cognitive functions possess important roles in mental and physical well-being of human. Healthier cognition functions is directly associated with lower risk of certain psychiatric disorders and physical illness in the later life course with reduced mortality risk. Cognitive decli [....] » Read More
Methylmercury (MeHg+) is a known neurotoxin that causes progressive motor neuron degeneration in the central nervous system. Axonal degeneration, oligodendrocyte degeneration, and myelin basic protein (MBP) deficits are among the neuropathological abnormalities caused by MeHg+ in [....] » Read More
• Burnout is higher among both physicians and basic scientists due to work demands and loss of some social connectivity during COVID and only adding obligations of wellness surveys or training can add to the workload burden and so care needs to be put into [....] » Read More
First applications of RNA analysis in human genetics aimed mainly at detecting splicing defects and loss or gain of gene expression. More recent developments of RNA-analyses are focusing on the use of gene expression changes as biomarkers for disease diagnostic, monitoring respon [....] » Read More
Objective: Recently, there are few reports on the long-term prognosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We aimed to clarify the long-term prognosis and prognostic factors of CIDP. Methods: Fifty-one consecutive patients with CIDP who had atte [....] » Read More
Parkinson’s disease is a neurological movement disorder caused by the progressive degeneration of dopamine producing cells in the substantianigra. Progressive degeneration of these cells developed in cardinal symptoms of Parkinson’s disease, which include tremor, [....] » Read More
Artificial intelligence (AI), often known as the fourth industrial revolution 4.0, will alter not only the way we do things and interact with people, but also our understanding of ourselves. Without directly affecting human connections AI, sparked a massive social shift. Mo [....] » Read More
Intriduction. Patients with arthrogryposis multiple congenital (AMC) have upper limbs deformities in up to 95% of cases. They usually have a typical appearance: the shoulder is held in adduction and internal rotation, the elbow in extension (less often in flexion), the wrist [....] » Read More
Ziconotide is a synthetic, water-soluble cone snail venom-derived peptide with a molecular weight of 2,639 Daltons. It is a nonopioid analgesic that selectively binds to N-type voltage-sensitive calcium channels on primary nociceptive afferent nerves in the dorsal horn of the spi [....] » Read More
Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is a rare disease with diagnosis offered by the Unified Health System in Brazil. Medical Genetics Service of Hospital de Clínicas de Porto Alegre, is a center of reference in service for rare disease, receivin [....] » Read More
Depression is one of the most common mental disorders worldwide. Depression involves intense feelings of sadness that endure long enough to interfere with one’s daily life and manifest differently in men and women according to social, biological, and psychological factors [....] » Read More
Title : Exploring the psychophysical phenomena; Fibromyalgia, Myalgic Encephalomyelitis/Chronic fatigue syndrome (ME), Postural Orthostatic Tachycardia Syndrome (POTS) and introducing novel approaches for effective Neurophysics treatment for these physical and mental health compromising conditions
Ken Ware, NeuroPhysics Therapy Institute, Australia
There is an ever-increasing number of people around the world who reportedly suffer from one or more of the psychophysical conditions Fibromyalgia, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME), Postural orthostatic tachycardia syndrome (POTS). In the USA there are pres [....] » Read More
Title : Spontaneous Neurological Recovery (SNR) following Traumatic Spinal Cord Injuries (TSCI)
W S El Masri, Keele University, United Kingdom
Prior to the 2nd world war and for thousands of years TSCI challenged, frustrated and defeated the medical profession and the majority of patients died from a range of complications within two years of injury. During the 2nd world war Ludwig Guttmann (Neurosurgeon) in the UK d [....] » Read More
Title : Temporomandibular Disorders vs Trigeminal Neuralgia: How TMD has continued to fool Neurologists!
Ben A Sutter, University of Medicine and Dentistry of New Jersey, United States
Trigeminal Neuralgia has perplexed clinicians and researchers for centuries. There is so much conflicting literature on the etiology of this rare and debilitating disease. In this presentation we will explore new explanations and diagnostic capabilities that shed ligh [....] » Read More
Title : The varieties of brain resonances and the conscious experiences that they support
Stephen Grossberg, Boston University, United States
Will be Updated Soon...
Title : The bladder cooling reflex and its clinical application
Chonghe Jiang, The Sixth Affiliated Hospital of Guangzhou Medical University, China
The ice-water test is a simple supplementary urodynamic test that is useful in differenting neurogenic from non-neurogenic bladder dysfunctions. Bors and Blinn some 50 years ago reported that rapid filling of the bladder with a small volume of ice water caused an immediate [....] » Read More
Title : Single microvessel occlusion technology (PLP) produces lamina-specific microvascular flow effects and neuronal degeneration
Xi Wang, Zhejiang University, China
There is increasing recognition that dysfunctions of microvasculature in the brain may underlie neurodegenerative disease. To understand the functional architecture of cortical microvasculature, we developed a highly precise photothrombosis method (ULPT) to occlude single microca [....] » Read More
Title : Ultra-early screening of Slight Cognitive Decline
Pengxu Wei, National Research Centre for Rehabilitation Technical Aids, China
Adults with the risk of dementia may present reduced cognitive performance several decades before the typical onset of Alzheimer's disease (AD). It is necessary to detect slight cognitive decline in an early stage for timely initiating active interventions. The slight cogniti [....] » Read More
Title : Intestinal flora composition determines microglia activation and improves epileptic
Ming Zhang, North Sichuan Medical College, China
In response to environmental stimuli, immune memory mediates the plasticity of myeloid cells. Immune training and immune tolerance are two aspects of plasticity. Microglia that are immunologically trained or immunologically tolerant are endowed with a tendency to differentiate in [....] » Read More
Title : The effects of arm exercise on trunk function in individuals with spinal cord injury
Shinyi Chloe Chiou, University of Birmingham, United Kingdom
Abstract: Short Description of what will be discussed during the presentation Objectives: Many people living with spinal cord injury (SCI) exhibit reduced trunk control which can severely compromise the use of upper and lower extremities, hindering functional recovery. Current [....] » Read More
Title : Psychosocial Dimensions on adherence to treatment regime in hemodialysis: A crossover between Social Work and Neurology
Maria Joao Sacadura, Psychology and Educational Sciences of Coimbra, Portugal
The aim of the present communication is to share some results of the data analysis of a PhD Social Work investigation in progress in Portugal, that focus the determinant factors of adherence to treatment regime in the context of end-stage renal disease. In the field of chronic an [....] » Read More
Title : CIRS-LAS - Outstandingly Improve Quality of Preclinical Studies and Animal Welfare
Sabine J Bischoff, Jena University Hospital, Animal Welfare Unit, Germany
Preclinical studies are an important step on the way to new knowledge in the fields of neurology. Animal experiments are often used to validate newly developed drugs or to gain more knowledge about neurologic disorders. The use of laboratory animals is indispensable in this field [....] » Read More
Title : 2-Aminoethoxydiphenyl Borate Neuroprotects the Stroke Brain through Shortening of Peri-infarct Depolarizations and Enhanced Perfusion in the Ischemic Penumbra
Rocio Fernandez Serra, Universidad Politécnica de Madrid, Spain
Ischemic stroke is the cause of high number of deaths and disability-adjusted life years among older adults, with an increasing prevalence due to demographic changes. Secondary mechanisms of injury associated to stroke contribute to exacerbate the damage, thus enhancing the neuro [....] » Read More
Title : Bioanalytical methodologies for the study of phospholipids in Alzheimer disease
Jose Luis Gomez Ariza, University of Huelva, Spain
Phospholipids play an important role in living organisms’ lipid bilayers, acting as a structural barrier for cellular and subcellular protection, being a fundamental component for the correct function of membrane proteins, receptors and ion channels. In addition, phospholip [....] » Read More
Title : New insights in Neuron-Astrocyte communication: Astrocytic G protein coupled receptor heteromers and release of glutamate
Manuela Marcoli, University of Genova, Italy
It is increasingly recognized that neurons and astrocytes are co-actors in the communication in central nervous system (CNS). Central to the view of astrocytes as active contributors in brain signaling are the astrocytic receptors that respond to neurotransmitters and the [....] » Read More
Title : Non material theory of the psyche
Mikhail Reshetnikov, East European Institute of Psychoanalysis, Russian Federation
For 2000 years, scientists searched for material foundations of the psyche, which proves to be non-material, thus this paradigm should be changed. It has been proved that: 1) for 2000 years, most scientists mistook the concepts: while speaking about research and therapy [....] » Read More
Title : Audiogenic epilepsy model – Krushinsky-Molodkina strain rats: neurophysiology, genetics and behavior
Natalia Surina, Lomonosov Moscow State University, Russian Federation
The trait – audiogenic seizure proneness (audiogenic epilepsy, AE) in KM strain rats - is characterized by high expressivity and penetrance – the short latency (1-2 s) seizure fit in the 100 % of cases with maximal intensity of clonic and then tonic seizures of trunk [....] » Read More
Title : Emphasizing the main factors involved between the green zones created near the natural salted lakes or springs and the treatment of some nervous system disorders
Ana Despina Ionescu, National Institute for Chemical Pharmaceutical Research and Development-ICCF , Romania
In recent years, more and more data has become available about the benefits of green in and around towns and cities. Vegetation helps people to recover faster from illness; this reduces costs of healthcare and improves the patients’ quality of life. This aspect of introduci [....] » Read More
Title : The Clinical And Psychological Effect of COVID19 Pandemic on Neuromyelitis Optica Spectrum Disorder Patients.
Roshanak Mehdipour, Isfahan University of Medical Sciences, Iran (Islamic Republic of)
Coronavirus 2019 was a new coronavirus created a pandemic with high mortality. People with underlying disease and immune system suppression are potentially prone to infection. The nature of NMOSD disease as well as its treatment by immunosuppressants predisposes patie [....] » Read More
Title : Neurological development, Epilepsy, And the pharmacotherapy approach in children with congenital zika syndrome: Results from a two-year follow-up study
Maria Eulina Quiliao, Instituto da Criança of Hospital das Clinicas de São Paulo/USP, Brazil
Introduction Background: During the Zika virus epidemic in Brazil, from January 2015 to December 2018, there were 278,790 people infected, and of these approximately 22,000 women who were pregnant. Consequently, there was a considerable increase in the number of newborns (1 [....] » Read More
Title : Jahi McMath: A new state of disorder of consciousness
Calixto Machado, Institute of Neurology and Neurosurgery, Cuba
In this paper, I reviewed the case of Jahi McMath who was diagnosed as being in brain death (BD). Nonetheless, ancillary tests, performed 9 months after initial brain insult, showed conservation of intracranial structures, EEG activity, and autonomic reactivity to “Mother T [....] » Read More
Title : Introducing a Mindfulness-Based Protocol for Recovery from Stroke (MBRfS)
Lori A Gray, Western Michigan University, United States
Decades of research suggest that Mindfulness-Based Stress Reduction (MBSR) training supports a greater capacity to live with chronic medical conditions and contributes to lowering stress levels. This paper introduces a model for a Mindfulness-Based Recovery from Stroke (MBRfS) fo [....] » Read More
Title : Information Extraction from EHR and EEG Signals in search of a Potential Biomarker for ADHD diagnosis
Armaan Saith, Temple University, United States
ADHD is the most common neurobehavioral disorder of childhood characterised by inattention, impulsivity and motor hyperactivity. The estimated number of children ever diagnosed with ADHD, according to a national 2016 parent survey is 6.1 million (9.4%). An estimated 8.7 million a [....] » Read More