Preclinical studies are an important step on the way to new knowledge in the fields of neurology. Animal experiments are often used to validate newly developed drugs or to gain more knowledge about neurologic disorders. The use of laboratory animals is indispensable in this field of complex neurological research models and at the same time represents a great risk for the animals. In addition, the repetition of animal experiments is very time-consuming and cost-intensive. In preclinical trials, there are often a large number of animals that die unexpectedly or show an unexpected clinical course. These results are also an important step on the way to new insights. Transparent handling of these unforeseen and critical events is enormously important.

The CIRS-LAS portal offers the possibility for every person working with laboratory animals  to deal with these events transparently and openly, without fear of consequences. On CIRS-LAS.de, critical events and incidents can be entered anonymously if desired. A database offers the possibility to search for further cases concerning one's own

work. The database search as well as the exchange about the cases is reserved for registered users. This ensures a safe environment to discuss errors or serious critical events that may occur in preclinical trials, especially  with large animals.

Your contribution to CIRS-LAS leads to an exchange of experiences - so everyone can learn from each other and e.g. failed trials are not repeated. At the same time, the exchange and open discussion can contribute  to  safe  and  successful preclinical studies. By actively contributing to  CIRS-LAS.de,  everyone  involved  in  animal experimentation can make a contribution to more animal welfare, fewer laboratory  animals  and  a  transparent approach to animal experimentation!

 

What will audience learn from your presentation?

• Everybody who is working with laboratory animals can help to increase animal welfare and transparency in laboratory animal science by participation at CIRS-LAS
• We all learn from negative results or critical incidents if we speak about it!
• Reporting an incident takes only a few minutes but helps to think  about critical events  and is  an  important way to achieve a good error culture
• Research in the CIRS-LAS database can save money and time for further experiments.
• Use of the CIRS-LAS database supports the progress of science