Title : Comparative cognitive profile to decode the candidate genes and eQTLs associated with Schizophrenia and other psychiatric disorders
Abstract:
Cognitive functions possess important roles in mental and physical well-being of human. Healthier cognition functions is directly associated with lower risk of certain psychiatric disorders and physical illness in the later life course with reduced mortality risk. Cognitive decline is a central manifestation which is commonly seen in patients suffering with Schizophrenia and other psychiatric disorders causing focal impairment to brain structures mediating mild/moderate/severe cognition dysfunction which leads to affect memory, personality, behavior and decision making abilities etc. Over the years, numerous studies reported on psychiatric disorders, despite the incidence of cognitive impact in Schizophrenia and other psychiatric disorders, the candidate miRNAs and SNPs respect to cognition is reported less. In this study, an integrated pipeline was developed with text mining, GWAS and functional annotation studies were employed to identify gene/miRNA biomarkers and functional SNPs in the GWS loci and eQTL to decipher the genetic mechanism behind the cognitive function in Schizophrenia and other three major psychiatric disorders. Gene sets enrichment analysis was performed to discover the functional significance of predicted targets with cognitive effect in psychiatric disorders. Gene based association analysis and gene expression heatmap of different tissue types for the target genes have been identified. Disease associated eQTLs analysis demonstrated the tissue specific expression levels to the corresponding disorders. The study will give insights into the interrelationships between significant pathways and genes to explore the biological mechanisms and related functions from the relevant cortical region with respect to Schizophrenia and other three major psychiatric disorders. An enhanced comprehend of mechanisms facilitating the cognitive dysfunction in psychiatric disorders may aid in the characterization of disease scenario and in the development of new cognitive treatments, since the cognitive treatment and management still remains a lack in therapeutic need. These results will provide insight into putative mechanisms related to improvement of cognitive ability in patients with Schizophrenia and other psychiatric disorders, in order to find new potential drug targets.
Keywords
Cognition, Schizophrenia, Psychiatric disoders, GWAS, eQTLs, SNPs
What will audience learn from your presentation?
- Understanding the role of cognitive impairment in Schizophrenia and other psychiatric disorders, predicting the candidate genes and their functions and pathways.
- Identification of the role of genetic biomarkers in the progression of Schizophrenia and other psychiatric disorders.
- Comparative analysis on major four neuro -psychiatric disorders to unravel the association of cognitive impairment.
