Arthur P Bollon, Vitruvian BioMedical, United States
A DNA therapeutic vaccine, YM7555, for Alzheimer’s Disease (AD) that delivers, by intramuscular injection, four copies of the Abeta gene and four copies of a section of the TAU gene results in reduction of accumulation of Abeta, TAU and 95% reduction of phosphorylated TAU ( [....] » Read More
Title : Neuro nanomedicine: Penetrating the blood brain barrier, delivering stem cells, treating stroke and meningitis, and so much more
Thomas J Webster, Interstellar Therapeutics, United States
Nanotechnology has revolutionized numerous industries, particularly medicine. Nanoparticles, nanotubes, drug delivery nanoparticles, and nanotextured neural probes are just several of many examples where nanomedicine is positively impacting neuroscience. This presentation will su [....] » Read More
Title : Live test for chronic wasting disease based on consistent association with an extreme thermoacidphilic bacterium
Frank Owen Bastian, Tulane Medical School, United States
The problem with controlling chronic wasting disease (CWD) infection in ruminants is there is no reliable live test for this devastating fatal encephalopathy. Our strategy is to use a disease biomarker to develop a live test for CWD. The most recognized biomarker [....] » Read More
Title : Therapeutic ketosis and the broad field of applications for the ketogenic diet: Ketone ester applications & clinical updates
Raffaele Pilla, St. John of God Hospital – Fatebenefratelli, Italy
It has been recently shown that nutritional ketosis is effective against seizure disorders and various acute/chronic neurological disorders. Physiologically, glucose is the primary metabolic fuel for cells. However, many neurodegenerative disorders have been associated with impai [....] » Read More
Title : Neuro Physics Therapy (NPT) shows to be a highly effective psychophysical treatment for its patients enduring advanced Facio Scapulohumeral Muscular Dystrophy (FSH, FSHD) symptoms, with significant sustainable generation of lost or highly compromised functions being realized in very small time scales
Ken Ware, NeuroPhysics Therapy Institute, Australia
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most frequent hereditary muscle disorders. It is said to be a ‘genetic’ muscle disorder in which the muscles of the face, shoulder blades, and upper arms are among the most affected. This presentatio [....] » Read More
Title : The association between pupil reactivity and cognitive measures among community-dwelling middle-aged and older adults
Yanjun Chen, University of Wisconsin Madison, United States
Aims: The pupillary light reflex (PLR) has been widely used to reflect visual function and brain activities, making it a potential biomarker for central nervous system (CNS) neurodegeneration. In this cross-sectional study, we evaluated the association between the PLRs and cognit [....] » Read More
Title : Transcranial laser photobiomodulation on posterior reversible encephalopathy syndrome
Juan Moreira, CNC / Gnosis Neurointegrative Center, United States
Posterior Reversible Encephalopathy Syndrome (PRES) have been described as a clinicoradiological syndrome characterized by acute ruptured of the Blood Brain Barrier and development of vasogenic edema secondary to acute endothelial injury. MRI shows predominantly reversible pariet [....] » Read More
Title : Transcranial photobiomodulation on acute & subacute stroke patients
Juan Moreira, CNC / Gnosis Neurointegrative Center, United States
The limited time for a therapeutic window of intravenous thrombolysis have been a problem since it’s approval twenty eight years ago. The availability of a stroke team for thrombectomy or intravenous thrombolysis , and the complexity of the eligibility criteria may be facto [....] » Read More
Title : HIV infection of human IPSC-derived microglia-containing cerebral organoids
Wenzhe Ho, Temple University Lewis Katz School of Medicine, United States
Studying the mechanism(s) of HIV-associated neurocognitive disorders (HAND) requires an appropriate in vitro brain model. In this study, we developed a human induced pluripotent stem cell (hiPSC)-derived cerebral organoids which contain not only astrocytes, neurons, and neural st [....] » Read More
Title : Impact of exercise intensity on cerebral BDNF levels: Role of FNDC5/Irisin
Clemence Leger, University of Burgundy, France
Physical exercise (EX) is an essential approach to improve physical and brain health. It is well known that positive effects of EX on brain involve the upregulation of cerebral BDNF (brain-derived neurotrophic factor), which promotes neuronal plasticity and cognit [....] » Read More
Title : A randomized double-blind clinical trial on the efficacy of transcranial direct current stimulation in reducing alcohol consumption in non-abstinent patients with alcohol use disorder
Anastasia Demina, Dijon Bourgogne University Hospital, France
Background: Recent studies suggest that transcranial direct current stimulation (tDCS) targeting the dorsolateral prefrontal cortex (DLPFC) result in significant alcohol craving reduction. To study the impact of tDCS on alcohol use outcomes, we designed a randomized double-blind [....] » Read More
Title : Effect of alpha-mangostin in the prevention of behavioural and neurochemical defects in methylmercury-induced neurotoxicity in experimental rats
Sumit Kumar, ISF College of Pharmacy, India
Methylmercury (MeHg+) is a known neurotoxin that causes progressive motor neuron degeneration in the central nervous system. Axonal degeneration, oligodendrocyte degeneration, and myelin basic protein (MBP) deficits are among the neuropathological abnormalities caused by MeHg+ in [....] » Read More
Title : Immune responses in multiple sclerosis: A neuro-autoimmune disorder
Shripad A Patil, National Institute of Mental Health and Neurosciences, India
Multiple sclerosis is a neuro-autoimmune disorder triggered mainly by auto-reactive T cells. Chronic inflammation, demyelination and gliosis are pathological conditions encountered. Perivascular white matter changes with punched out lesions and generalized atrophy is seen in brai [....] » Read More
Title : Neuromyelitis optica spectrum disorder: An indian perspective
Shankar Prasad Saha, Nil Ratan sircar Medical College, India
Neuromyelitis Optica is an autoimmune astrocytopathy that affects the spinal cord, optic nerves and the brain. With the development of the AQP4 Antibody in 2004, this disease has come to be recognised as a distinct entity from Multiple Sclerosis and Myelin oligodendrocyte Glycopr [....] » Read More
Title : Calculation of the fragility index of randomized controlled trials in epilepsy published in twelve major journals
Suja Xaviar, SMVMCH (Sri Manakula Vinayagar Medical College Hospital), India
Objective: Fragility index is the minimum number of participants in a trial whose status has to be changed from an ‘event’ to a ‘non-event’ for a dichotomous primary outcome to turn the P-value (calculated by Fischer’s exact test) statistically non-s [....] » Read More
Title : Chronic stress and pathophysiology of neuropsychiatric diseases
Meenal Dhall, University of Delhi, India
Stress is a major contributor to the development of various neuropsychiatric diseases. Stress hormones impact cognitive and mental health, and prolonged stress can result in significant biochemical and anatomical changes in the brain. The current understanding of these disorders [....] » Read More
Title : The relationship between depressive symptoms and cognitive function in Alzheimer’s Disease: The mediating effect of amygdala functional connectivity and radiomic features
Yang Du, Shanghai Mental Health Centre, Shanghai Jiaotong University, China
Background: Depressive symptoms are common in Alzheimer's disease (AD) and are associated with cognitive function. Amygdala functional connectivity (FC) and radiomic features related to depression and cognition. However, studies have yet to explore the neural mech [....] » Read More
Title : A novel deletion variant in CLN3 with highly variable expressivity is responsible for juvenile neuronal ceroid lipofuscinoses
Naser Gilani, Farabi Medical Laboratory, Iran (Islamic Republic of)
With more than 7,000 identified rare diseases and approximately 80 % being linked to genetic causes, diagnosing rare disease patients can often be difficult – resulting in lengthy, expensive, and emotional diagnostic odysseys, but with revolutionary advances in Molecular [....] » Read More
Title : Effects of amantadine on acute stroke: A randomized, double blind, placebo-controlled trial.
Mehdi Sheikhi, AJA University of Medical Sciences, Iran (Islamic Republic of)
Stroke is a leading cause of morbidity and second cause of mortality worldwide. Early participation in rehabilitation treatments such as neurostimulant drugs showed to be beneficial. Amantadine usually used as Parkinson disease treatment, is prescribed in patients with traumatic [....] » Read More
Title : Comparison of the effects of sliding mechanism and reciprocating hinge-type medial linkage of knee-ankle-foot orthoses on walking ability in subjects with spinal cord injury
Mokhtar Arazpour, University of social welfare and rehabilitation sciences, Iran (Islamic Republic of)
Objectives: This study evaluated the efficacy of two different medial linkage mechanisms (sliding mechanism (SM) and medial linkage mechanism associated with reciprocating gait motion (MLRGM)) used on patients with spinal cord injury (SCI). Methods: Eight volunteer SCI su [....] » Read More
Title : Brain-blood vessels development at first seven days of incubation of the wild helmeted guinea fowl (Numida meleagris galeata). The incubation period
Wanmi Nathaniel, University of Agriculture, Nigeria
The wild helmeted guinea fowl has in recent time been used for research in the field of anatomy because of its peculiarity from other domesticated species of avian. Eggs of the wild helmeted guinea fowl are considered to be nutritious and has been used for medicinal purposes in s [....] » Read More
Title : Implementation of a scalable tablet-based assessment tool to detect children at risk of developmental delay in Malawi
Vukiwe Ngoma, Blantyre Malaria Project, Malawi
Background: A key obstacle in detecting mental health problems in young children in low-to-middle income countries(LMICs) is the lack of scalable and standardized tools.Commonly used tools are proprietary, time-intensive, expensive, and require highly skilled professionals to adm [....] » Read More
Title : Synaptic and related structure modifications induced by perinatal asphyxia
Francisco Capani, CAECIHS.UAI-CONICET, Argentina
Transient interruption of oxygen supply close to delivery causes an obstetrical complication known as perinatal asphyxia (PA). The estimated incidence of this life-threatening complication ranges from 1 to 8 up to 26 per 1,000 live births in developed and developing countries, re [....] » Read More
Title : Factors limiting the neurofeedback training efficiency
Olga M Bazanova, State Research Inst. Neuroscience and Medicine, Russian Federation
The Neurofeedback training (NFT) technologies pursue the goal – the voluntary modification of the neurophysiological process affecting the cognitive and psychomotor activity. Therefore, an analysis of the literature regarding NFT efficiency can be beneficial for a deeper un [....] » Read More
Title : DNA process in fractal cells
Kais Bouallegue, University of Sousse, Tunisia
Computational biology faces the challenge of modeling the complex dynamical processes that underlie cellular functions, which evolve and change depending on internal functional requirements and external environmental factors. To address this challenge, researchers have turned to [....] » Read More
Title : Case series on brain stimulation using TPS: Sustained therapeutic effects even in early Alzheimer’s disease
Ali Riza Gunes, Alexius/Josef Hospital Neuss, Germany
Background Alzheimer's dementia (AD) is the most common form of dementia worldwide, affecting 1.8 million people in Germany alone. Various forms of therapy are available, yet AD cannot be stopped, even with innovative approaches such as monoclonal antibodies. The therape [....] » Read More
Title : On the role of histaminergic and PPAR mechanisms of the brain in the development of chronic pentylenetetrazole-induced seizures
Yehorenko Olha, Odesa National Medical University, Ukraine
Background and Aims: Histamine, an essential mediator of inflammation, is also synthesized by neurons and ensures control of their excitability.The work aimed to investigate the effects of the histamine H₃ inverse agonist pitolisant hydrochloride and pioglitazone, wh [....] » Read More
Title : Working memory capacity and mind wandering during reading comprehension in a sample of Arabic native speakers of UAE
Dalia Bedewy, Ajman University, United Arab Emirates
Studies examining mind wandering (MW) has increased and is notably documented in literature. The relationship between working memory capacity (WMC) and mind wandering has been a controversial issue for some times. Where Randall, Oswald, & Beier, 2014 has shown that Individual [....] » Read More
Title : Poorly differentiated clival chordoma in extreme young age; Case illustration and review of literature
Malak Marzouk Mohammed Altewerki, King Faisal Speicalist Hospital &Research center, Saudi Arabia
Chordomas are rare tumors believed to be originated from notochordal remnants. Of all intracranial neoplasms, the incidence of cranial chordomas is less than 1%1. The youngest patient with an intracranial chordoma reported in the literature was a newborn in the first few days aft [....] » Read More
Title : Evaluating the individual and synergistic neuroprotective effect of withaferin a and tinospora cordifolia extract in kainic acid-induced neurodegeneration
Randeep Singh, Central University of Punjab, India
Kainic acid-induced status epilepticus (KASE) is a well-studied and validated model of the most common form of epilepsy, i.e., temporal lobe epilepsy (TLE). KA is a neurotoxin that elicits seizures in vivo and cell membrane and nuclear disintegration in vitro. Withafe [....] » Read More
Title : ADHD in children - Physical and psychological effects
Zeynep Elif Olmez, Hisar School, Turkey
Attention deficit/hyperactivity disorder which is popularly known as ADHD, is one of the most common mental illnesses affecting children. The effects of ADHD are known to affect a person in many areas of their life, including academic and professional success, rel [....] » Read More
Title : Neural circuit and brain structure change in women with PTSD
Tansa Nisan Gunerhan, Hisar School, Turkey
PTSD (post-traumatic stress disorder) is a neurodegenerative disease that is caused by tragic, unfortunate events such as violation, physical/mental abuse, and combat exposure. PTSD is linked with elevated levels of cortisol and noradrenaline (hormones) responses to stressors. Th [....] » Read More
Title : Pain control theories
Begum Bulgurluoglu, Hisar School, Turkey
Neuroscientists Ronald Melzack and Patrick Wall put forth a revolutionary new theory of pain in the 1960s. Researchers at the time were having trouble explaining the phenomenon. While some asserted that the pain signals are delivered by the intensive firing of non-speci [....] » Read More
Title : The basis of decision-making
Mia Bahar, Hisar School, Turkey
Our days are assembled from thousands of small decisions: what to do, which way to go, how to respond, whether to partake, and our brain is made of many competing networks each with its own goals and desires. One neuron itself doesn't have an efficient power. T [....] » Read More
Title : Human brain mapping - The golden future of neuroscience
Lara Hanci, Hisar School, Turkey
The brain, being the most complex organ in the human body, can’t be completely understood with today’s technology. Therefore, there mostly aren't certain cures for brain diseases such as Alzheimer's disease, dementias, brain cancer, epilepsy, mental [....] » Read More
Title : The application of brain-machine interface for prosthetic limb development
Lara Ann Tureli, Hisar School, Turkey
The applications of Brain-Machine Interface (BMI) are relatively recent. It is believed that BMI first started being researched and tested in the 1970’s. In its first applications, noninvasive methods were used to control a cursor-like graphical object on a machine screen t [....] » Read More
Title : The neurological basis of narcolepsy and how It affects daily life
Selin Edil, Hisar School, Turkey
Extreme daytime drowsiness, cataplexy, and an early beginning of rapid eye movement sleep are all symptoms of the chronic neurologic illness narcolepsy. It can be distinguished from other conditions that can induce daytime drowsiness by its clinical signs and by sleep laboratory [....] » Read More
Title : Optogenetics on nonhuman primates
Arda Ozkurt, Hisar School, Turkey
Optogenetics is a method to activate or deactivate genetically modified neurons by using light. It has been a useful tool to discover new neural circuits since it was first used in 2004. In the early experiments, especially mice, rats, and fruit flies were used. T [....] » Read More
Title : How trauma changes the brain
Nil Atay, Enka Schools, Turkey
Researchers are learning more about how traumatic events affect our brains physically. Changes in a brain mechanism used for learning and survival have been discovered by neurologists to play a role in how someone responds to a threat following a traumatic experience. Another stu [....] » Read More
Title : Curative effects of grape seed extract on pilocarpine induced epilepsy model in rodents
May Melki, University of Carthage, Tunisia
Background and aim: Temporal lobe epilepsy is a complex, partial form of epilepsy with well-known effects on the nervous system. It is the most common form of epilepsy. The majority of epileptic patients become pharmaco-resistant to antiepileptic treatments, which leads researche [....] » Read More
Title : Influence of psychosocial factors on the structure of dementia syndrome
Alena Sidenkova, FSBEI HE Uralsk State Medical University of the Ministry of Health of Russia, Russian Federation
Background: The growing prevalence of severe cognitive impairment in populations, the involvement of a significant number of people of working age in the medical, economic, psychological and social problems associated with late dementia, the insufficiency and inconsistency of inf [....] » Read More