Facioscapulohumeral muscular dystrophy (FSHD) is one of the most frequent hereditary muscle disorders. It is said to be a ‘genetic’ muscle disorder in which the muscles of the face, shoulder blades, and upper arms are among the most affected. This presentatio [....] » Read More
Objective: To investigate the effect of and Acupuncture on brain plasticity and motor development in children with cerebral palsy. Investigate effect on mechanism of apoptosis of brain nerve cells, regulating the expression of neurotrophic factors, promoting the remodeling o [....] » Read More
Popular stereotypes of addiction emphasize loss of free will, sometimes based on irresistible urges. The recently popular “brain disease” theory of addiction likewise emphasizes on the inability to stop using despite wanting to quit. But evidence suggests that addicts [....] » Read More
The problem with controlling chronic wasting disease (CWD) infection in ruminants is there is no reliable live test for this devastating fatal encephalopathy. Our strategy is to use a disease biomarker to develop a live test for CWD. The most recognized biomarker [....] » Read More
Research suggests that the cumulative stress of caring for a person with a chronic neurological disorder can contribute to burnout, both among physicians (“physician burnout” and patient families (“caregiver burnout Expressive arts techniques have been [....] » Read More
Policy formation in the field of individual health promotion and protection is one of the priority tasks of national healthcare systems. Canonical health care is becoming increasingly unaffordable in most of the countries, yet it remains ineffective in preventing or effectively t [....] » Read More
Background: Ischemic stroke is a serious disease which can result in physical disability and death. The protective effect of miRNA up-regulated exosomes derived from neural stem cells (NSCs) on ischemic stroke and its molecular mechanism were investigated, aiming to reveal the th [....] » Read More
Ziconotide is a synthetic, water-soluble cone snail venom-derived peptide with a molecular weight of 2,639 Daltons. It is a nonopioid analgesic that selectively binds to N-type voltage-sensitive calcium channels on primary nociceptive afferent nerves in the dorsal horn of the spi [....] » Read More
Neurotransmitter is an essential for synaptic transmission in the mammalian central nervous system, and is involved in all brain functions and in various neurological diagnoses. Vesicular neurotransmitter transporters (VNTs) are one of major syanptic vesicle proteins. They transp [....] » Read More
Background: Mild cognitive impairment (MCI) represents an intermediate state between normal cognitive aging and dementia. We aimed to investigate the asso- ciation and mediation pathways of sarcopenia, including its individual components (muscle mass, muscle strength, and physica [....] » Read More
Mice hippocampus contains three prominent subregions, CA1, CA3 and DG and is well regarded as an essential multiple task processor for learning, memory and cognition based on tremendous studies on these three subregions. The narrow region sandwiched between CA1 and CA3 called CA2 [....] » Read More
Objective: Chronic insomnia disorder (CID) affects people's daytime function and is also a risk factor for many diseases. Targeted drugs have obvious side effects. The therapeutic effect of acupuncture on CID has been confirmed by clinical studies, but there is still a lack [....] » Read More
Neuroplasticity is the main characteristic of the adaptive properties of the brain, which ensure the self-organization of complex hierarchical and multi-relational connections within and between neural networks, during normal growth and development and under pathological conditio [....] » Read More
Biomarkers enable pre-early diagnosis, guide targeted therapy and monitor the active ty and therapeutic responses across the diseases. Among the best-validated predictive biomarkers are autoimmunity-related ones to predict and prognosticate risks of the chronification, complicati [....] » Read More
We found a small piece in the puzzle of long-term memory. This finding identified the odd phenomenon implicating PARP1, a protein that initiates the repair of DNA breaks, in synaptic potentiation and in long-term memory formation during learning. The identified molecular mechanis [....] » Read More
In this talk I first review and discuss empirical evidence regarding brain damage and neural abnormalities associated with some psychopathologies and cognitive deficits, such as hemispatial neglect, agnosia, schizophrenia, amnesia, somatoparaphrenia, akinetopsia, Capgras syndrome [....] » Read More
Due to damage brought on by cerebrovascular occlusion or hemorrhage, the brain struggles to obtain the same amount of oxygen to the afflicted regions of a stroke. A novel protocol utilizing hyperbaric oxygen therapy (HBOT), has been proven to improve neurocognitive and neuro [....] » Read More
Arteriovenous Malformations (AVMs) are an anomaly of the vascular system where feeding arteries are directly connected to the venous drainage network. While AVMs can arise anywhere in the body and have been described in most tissues, brain AVMs are of significant concern because [....] » Read More
The majority of GWAS mutations are in noncoding regions, making it challenging to pinpoint the true disease-causal mutations in a complex linkage disequilibrium (LD) block and quantify their causality. To address this problem, we developed a deep learning (DL) algorithm that accu [....] » Read More
Neuromuscular disorders (NMD) are debilitating conditions that often lead to early morbidity and mortality due to progressive weakness. In the last decade, the treatment of NMD has undergone a remarkable advancement and we now we have several therapeutic options for these patient [....] » Read More
The talk will elucidate how certain imaging techniques that are currently used in research can be applied to clinical diagnoses and help the surgeons, neurologists and epileptologists make better decisions. Recent Advances in functional MRI, DTI tractography and Spectroscopy c [....] » Read More
In the hippocampus, new neurons are generated throughout life via a process called adult hippocampal neurogenesis (AHN). In mild cognitive impairment (MCI) and mild to moderate AD (early AD), AHN is reduced suggesting that AHN impairment compromises hippocampal function. Accord [....] » Read More
Alzheimer's Disease (AD) is a major cause of cognitive/memory impairment and dementia. Amyloid beta (Aβ) is an extracellular 39-43 residue long peptide whose aggregation is associated with Alzheimer’s disease (AD) and it’s accumulation represents one of the k [....] » Read More
Background: According to the “Hemispheric Asymmetry Reduction in older Adults” model (HAROLD; Cabeza, 2002) healthy elderly (HE) may show bilateral cortical activity patterns compared to younger subjects showing more left lateralized cortical activity. The HAROLD [....] » Read More
Brain-machine teaming is a collaborative interfacing system between the human brain and external machines. It is a bidirectional communication concept based on the brain-machine interface (BMI). Especially, electroencephalogram (EEG)-based BMI has been utilized to help patients r [....] » Read More
The current state of the problem of polymorphism of the clinical picture of vestibular migraine and objectification of the vestibular component remains unresolved and require further research.The purpose of our study was to study the clinical features and the possibility of objec [....] » Read More
Depression is one of the main mental disorders requiring hospitalization, fraught with the incidence of suicide attempts. Statistics indicate that depression is twice as common in women as in men; it affects middle-aged people, but also the elderly and children and adolescents. R [....] » Read More
Background: Posterior circulation ischaemic strokes (PCIs) are a clinical syndrome associated with ischemia or embolic occlusion of posterior circulation and differ from anterior circulation ischaemic strokes (ACIs) in many aspects. In this study, ACIs and PCIs were evaluated in [....] » Read More
Pain is one of the most frequent complaints of patients, being responsible for causing damage to the public health system, disability, and loss of functionality to patients. Understanding the different levels and types of Pain and its possible musculoskeletal dysfunctions is ess [....] » Read More
Objective: The goal of our research was to objectively evaluate the safety and efficacy potential of two investigational treatment regimens using rhFGF18 and rhGDF11 for the treatment of ischemic stroke. Background: Despite recent advances in prevention and treatment, stroke r [....] » Read More
Brain-machine teaming is a collaborative interfacing system between the human brain and external machines. It is a bidirectional communication concept based on the brain-machine interface (BMI). Especially, electroencephalogram (EEG)-based BMI has been utilized to help patients r [....] » Read More
Brain-machine teaming is a collaborative interfacing system between the human brain and external machines. It is a bidirectional communication concept based on the brain-machine interface (BMI). Especially, electroencephalogram (EEG)-based BMI has been utilized to help patients r [....] » Read More
The diagnosis of epilepsy relies on careful analysis of electroencephalograph (EEG) records to understand the underlying mechanisms of epileptic disorders. Due to noise interference, filtering is necessary before applying feature extraction and classification. Traditional frequ [....] » Read More
Lecanemab is the humanized IgG1 version of the mouse monoclonal antibody mAb158, which selectively binds to large, soluble Aβ protofibrils [1]. On January 6, 2023, Lecanemab (Leqembi) was approved by the FDA under an accelerated approval pathway based on the observed redu [....] » Read More
Introduction: Management of Traumatic Brain Injury (TBI) is currently aimed at secondary brain injury prevention that results from brain ischemia. Remote ischemic conditioning (RIC) is a non-invasive intervention that has been shown to lessen ischemia/reperfusion injury and poten [....] » Read More
Introduction: The status epilepticus is a neurological emergency that needs intensive measures and also has high mortality. The International Leage Against Epilepsy (ILAE) in 2015 sets a new definition: is a condition resulting either from the failure of the mechanisms responsibl [....] » Read More
The Acetyl-cholinesterase enzyme, also noted AcHE, has the code - EC 3.1.1.7, being an enzyme that degrades by hydrolysis the acetylcholine (AcH) neurotransmitter in choline and acetate. In vivo, this enzyme is found at neuromuscular junction or cholinergic synapses from th [....] » Read More
Objective: Synaptic dysfunction is one of the early symptoms of AD, which occurs much earlier than the formation of amyloid plaques and neurofibrillary tangles. Synaptic function is closely related to the number and synaptic localization of AMPA receptors (AMPARs), and this [....] » Read More
Addiction can be defined as an irresistible desire for an object, individual or entity although it is known to be harmful to the person physically or psychologically. In addiction physical dependence is explained as changes in the brain structure. In addition to ca [....] » Read More
Introduction: Sexual Dysfunction (SD) following dysfunction of the pelvic floor muscles (PFM) is perceived to be more common in women with Multiple Sclerosis (MS) than in the general population. Studies report a prevalence of up to 80% in women. SD is a painful but still und [....] » Read More
Decades of research suggest that Mindfulness-Based Stress Reduction (MBSR) training supports a greater capacity to live with chronic medical conditions and contributes to lowering stress levels. This paper introduces a model for a Mindfulness-Based Recovery from Stroke (MBRfS) fo [....] » Read More
Objective: Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with two core symptoms, namely repetitive stereotyped behaviors and impairments in social interaction. Neuroligin1 (NLG1) is one of synaptic adhesion molecules, which is a high-risk molecule fo [....] » Read More
Title : Transcranial laser photobiomodulation on posterior reversible encephalopathy syndrome
Juan Moreira, CNC / Gnosis Neurointegrative Center, United States
Posterior Reversible Encephalopathy Syndrome (PRES) have been described as a clinicoradiological syndrome characterized by acute ruptured of the Blood Brain Barrier and development of vasogenic edema secondary to acute endothelial injury. MRI shows predominantly reversible pariet [....] » Read More
Title : Neuro nanomedicine: Penetrating the blood brain barrier, delivering stem cells, treating stroke and meningitis, and so much more
Thomas J Webster, Interstellar Therapeutics, United States
Nanotechnology has revolutionized numerous industries, particularly medicine. Nanoparticles, nanotubes, drug delivery nanoparticles, and nanotextured neural probes are just several of many examples where nanomedicine is positively impacting neuroscience. This presentation will su [....] » Read More
Title : The association between pupil reactivity and cognitive measures among community-dwelling middle-aged and older adults
Yanjun Chen, University of Wisconsin Madison, United States
Aims: The pupillary light reflex (PLR) has been widely used to reflect visual function and brain activities, making it a potential biomarker for central nervous system (CNS) neurodegeneration. In this cross-sectional study, we evaluated the association between the PLRs and cognit [....] » Read More
Title : Transcranial photobiomodulation on acute & subacute stroke patients
Juan Moreira, CNC / Gnosis Neurointegrative Center, United States
The limited time for a therapeutic window of intravenous thrombolysis have been a problem since it’s approval twenty eight years ago. The availability of a stroke team for thrombectomy or intravenous thrombolysis , and the complexity of the eligibility criteria may be facto [....] » Read More
Title : Impact of exercise intensity on cerebral BDNF levels: Role of FNDC5/Irisin
Clemence Leger, University of Burgundy, France
Physical exercise (EX) is an essential approach to improve physical and brain health. It is well known that positive effects of EX on brain involve the upregulation of cerebral BDNF (brain-derived neurotrophic factor), which promotes neuronal plasticity and cognit [....] » Read More
Title : Case series on brain stimulation using TPS: Sustained therapeutic effects even in early Alzheimer’s disease
Ali Riza Gunes, Alexius/Josef Hospital Neuss, Germany
Background Alzheimer's dementia (AD) is the most common form of dementia worldwide, affecting 1.8 million people in Germany alone. Various forms of therapy are available, yet AD cannot be stopped, even with innovative approaches such as monoclonal antibodies. The therape [....] » Read More
Title : A randomized double-blind clinical trial on the efficacy of transcranial direct current stimulation in reducing alcohol consumption in non-abstinent patients with alcohol use disorder
Anastasia Demina, Dijon Bourgogne University Hospital, France
Background: Recent studies suggest that transcranial direct current stimulation (tDCS) targeting the dorsolateral prefrontal cortex (DLPFC) result in significant alcohol craving reduction. To study the impact of tDCS on alcohol use outcomes, we designed a randomized double-blind [....] » Read More
Title : DNA process in fractal cells
Kais Bouallegue, University of Sousse, Tunisia
Computational biology faces the challenge of modeling the complex dynamical processes that underlie cellular functions, which evolve and change depending on internal functional requirements and external environmental factors. To address this challenge, researchers have turned to [....] » Read More
Title : Comparison of the effects of sliding mechanism and reciprocating hinge-type medial linkage of knee-ankle-foot orthoses on walking ability in subjects with spinal cord injury
Mokhtar Arazpour, University of Social Welfare and Rehabilitation Sciences, Iran (Islamic Republic of)
Objectives: This study evaluated the efficacy of two different medial linkage mechanisms (sliding mechanism (SM) and medial linkage mechanism associated with reciprocating gait motion (MLRGM)) used on patients with spinal cord injury (SCI). Methods: Eight volunteer SCI su [....] » Read More
Title : A novel deletion variant in CLN3 with highly variable expressivity is responsible for juvenile neuronal ceroid lipofuscinoses
Naser Gilani, Farabi Medical Laboratory, Iran (Islamic Republic of)
With more than 7,000 identified rare diseases and approximately 80 % being linked to genetic causes, diagnosing rare disease patients can often be difficult – resulting in lengthy, expensive, and emotional diagnostic odysseys, but with revolutionary advances in Molecular [....] » Read More
Title : The neurological basis of narcolepsy and how It affects daily life
Selin Edil, Hisar School, Turkey
Extreme daytime drowsiness, cataplexy, and an early beginning of rapid eye movement sleep are all symptoms of the chronic neurologic illness narcolepsy. It can be distinguished from other conditions that can induce daytime drowsiness by its clinical signs and by sleep laboratory [....] » Read More
Title : ADHD in children - Physical and psychological effects
Zeynep Elif Olmez, Hisar School, Turkey
Attention deficit/hyperactivity disorder which is popularly known as ADHD, is one of the most common mental illnesses affecting children. The effects of ADHD are known to affect a person in many areas of their life, including academic and professional success, rel [....] » Read More
Title : Neural circuit and brain structure change in women with PTSD
Tansa Nisan Gunerhan, Hisar School, Turkey
PTSD (post-traumatic stress disorder) is a neurodegenerative disease that is caused by tragic, unfortunate events such as violation, physical/mental abuse, and combat exposure. PTSD is linked with elevated levels of cortisol and noradrenaline (hormones) responses to stressors. Th [....] » Read More
Title : Pain control theories
Begum Bulgurluoglu, Hisar School, Turkey
Neuroscientists Ronald Melzack and Patrick Wall put forth a revolutionary new theory of pain in the 1960s. Researchers at the time were having trouble explaining the phenomenon. While some asserted that the pain signals are delivered by the intensive firing of non-speci [....] » Read More
Title : The basis of decision-making
Mia Bahar, Hisar School, Turkey
Our days are assembled from thousands of small decisions: what to do, which way to go, how to respond, whether to partake, and our brain is made of many competing networks each with its own goals and desires. One neuron itself doesn't have an efficient power. T [....] » Read More
Title : Human brain mapping - The golden future of neuroscience
Lara Hanci, Hisar School, Turkey
The brain, being the most complex organ in the human body, can’t be completely understood with today’s technology. Therefore, there mostly aren't certain cures for brain diseases such as Alzheimer's disease, dementias, brain cancer, epilepsy, mental [....] » Read More
Title : The application of brain-machine interface for prosthetic limb development
Lara Ann Tureli, Hisar School, Turkey
The applications of Brain-Machine Interface (BMI) are relatively recent. It is believed that BMI first started being researched and tested in the 1970’s. In its first applications, noninvasive methods were used to control a cursor-like graphical object on a machine screen t [....] » Read More
Title : Optogenetics on nonhuman primates
Arda Ozkurt, Hisar School, Turkey
Optogenetics is a method to activate or deactivate genetically modified neurons by using light. It has been a useful tool to discover new neural circuits since it was first used in 2004. In the early experiments, especially mice, rats, and fruit flies were used. T [....] » Read More
Title : How trauma changes the brain
Nil Atay, Enka Schools, Turkey
Researchers are learning more about how traumatic events affect our brains physically. Changes in a brain mechanism used for learning and survival have been discovered by neurologists to play a role in how someone responds to a threat following a traumatic experience. Another stu [....] » Read More