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9th Edition of International Conference on

Neurology and Neurological Disorders

June 20-22, 2024 | Paris, France

Neurology 2023

Narinobu Juge

Speaker at Neurology and Neurological Disorders 2023 - Narinobu Juge
Okayama University, Japan
Title : Identified new regulation of vesicular neurotransmitter transporters

Abstract:

Neurotransmitter is an essential for synaptic transmission in the mammalian central nervous system, and is involved in all brain functions and in various neurological diagnoses. Vesicular neurotransmitter transporters (VNTs) are one of major syanptic vesicle proteins. They transport neurotransmitter into synaptic vesicles for excitatory, inhibitory or emotional signal transmission in the central nervous system. VNTs are located not only on synaptic vesicles, but also on the plasma membrane during the transduction of neurons. VNTs are also involved in various biochemical regulation processes. I have clarified the some of molecular mechanisms of VNTs, I will talk about the lipid regulation of VNTs in this presentation.

Presynaptic terminals tightly control their lipid composition, and each lipid markedly regulates neuronal activity. The lipid compositions and protein orientations are different among synaptic vesicles and plasma membranes in presynaptic terminals and VNTs are localized on both membrane. Several physiological and pathological conditions induce changes in the lipid composition, and lipidomic changes are associated with neurological and psychiatric disorders.

In the present study, we demonstrate the lipid induced transporter activity and conformational changes. And this lipid regulation is linked to the transporter cycle during the neurotransmission. That is, VNTs actively accumulate neurotransmitters in synaptic vesicles, but upon exocytosis, they abruptly stop their transport and relase excess neurotransmitters. Because neurological and psychiatric disorders are also caused by abnormalities in vesicular neurotransmitter transporters, the lipidomic regulation of these transporters will serve as appropriate drug targets for these disorders. Thus, our findings could provide novel strategies for the treatment and prevention of neurological and psychiatric disorders.

Biography:

Narinobu Juge studied Pharmacological science at the Daiichi pharmaceutical University, Japan and graduated as BS in 2004. Then joined the research group of Prof. Yoshinori Moriyama at the Department of Molecular Membrane Biology, Okayama University Graduate School of Medicine, Dentistry, Pharmaceutical Sciences. I received her PhD degree in 2009 at the same institution. After two and half years postdoctoral fellowship supervised by Dr Robert Edwards at the UCSF, I obtained the position of an Assistant Professor at the Okayama University.

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