Keliang Xie

Title : Prevalence and risk factors for unruptured intracranial aneurysms in the population at high risk for aneurysm

Abstract:

Although the incidence of unruptured intracranial aneurysms (UIA) ranges from 2% to 5%, aneurysm rupture is a critical and critical condition in neurosurgery, posing a fatal threat to patients. The burden of UIA is considerable in stroke patients. However, the best prevention and management strategy for UIA is uncertain among patients with a family history of stroke. Therefore, this study aimed to determine the epidemiological characteristics and risk factors for UIA based on a population with a family history of stroke. This study used random sampling to recruit participants with a family history of stroke among rural residents in Jixian, Tianjin, China. All participants underwent a questionnaire survey, physical examination, and cervical computed tomography angiography (CTA). CTA data were used to determine whether the subjects had UIA. The relationship between relevant factors and UIA was assessed using logistic regression analysis. A total of 281 residents were recruited in this study, with a mean age of 50.9 years. The prevalence of UIA in those with a family history of stroke was 10.3% overall (9.8% among men and 10.9% among women). Moreover, with each unit increase in body mass index (BMI), the prevalence of UIA decreased by 12.5%. Particularly among non-obese men, BMI had a stronger protective effect (OR: 0.672; 95%CI: 0.499-0.906; P = 0.009), and among non-obese men, an increase in low-density lipoprotein (LDL) was associated
with an increased prevalence of UIA (OR: 3.638; 95%CI: 1.108-11.947; P = 0.033). Among the non-obese with a family history of stroke, BMI may be protective against UIA, especially in men. It is crucial to strictly control the LDL level in non-obese people to reduce the burden of UIA.

Audience Take Away Notes:

• The prevalence of intracranial aneurysms among people with a family history of stroke in northern China is 10.3%
• BMI may be a risk factor for unruptured intracranial aneurysms
• LDL may be a risk factor for unruptured intracranial aneurysms, especially in non obese males

Biography:

Professor Xie Keliang is currently the Director of the Department of Critical Care Medicine at Tianjin Medical University General Hospital. The doctor studied anesthesiology at Tianjin Medical University and was employed in the Department of Anesthesiology at Tianjin Medical University in 2009. Obtained a Doctor of Medicine degree in 2013. From 2011 to 2013, I joined Professor Jean Louis Vincent's research team at the Free University of Brussels for postdoctoral work. Published over 150 SCI papers, with 80 published as first/corresponding author. Accumulated IF=600+, highest IF=15.3.