Title : Rapidly progressive Subacute Sclerosing Panencephalitis (SSPE) in a young adult: A Case
Abstract:
Background: Subacute sclerosing panencephalitis (SSPE) is a rare, fatal complication of persistent measles virus infection. It typically affects children but can rarely present in adults with an aggressive course.
Case Report: A 22-year-old male presented with rapidly progressive cognitive impairment, myoclonic status epilepticus, and recurrent falls over two months. Routine investigations were normal. EEG revealed periodic slow-wave complexes, and MRI showed T2/FLAIR hyperintensities in periventricular and subcortical regions. CSF analysis confirmed elevated measles IgG antibody titers and a positive CSF/serum antibody quotient, diagnostic of SSPE.
Conclusion: This case emphasizes the rapid progression of SSPE in young adults, the diagnostic utility of EEG and CSF measles antibody testing, and the need for early recognition and supportive management.
Keywords: SSPE, Myoclonic Status, EEG, Measles Antibodies, Rapid Progression
