Title : Inflammatory profile and alpha-synuclein in Egyptian alzheimer’s and parkinson’s disease patients: A pilot cohort study
Abstract:
Alzheimer’s and Parkinson's disease are the most common neurodegenerative diseases. With the aging of the general populations, the prevalence of these diseases is on the rise .The imperative for early detection, non- invasive, cost effective biomarkers to reflect disease diagnoses and progression is now more pressing than ever .Traditionally, most of the data in the literature included patients from North America and Europe, but the recent advances in genetic studies have shown that, it is inevitable to include other underrepresented populations that have not been studied earlier in the field of neurodegenerative diseases . Most of the Egyptian available data reflect an increased prevalence of both AD and PD in upper Egypt comparing with other countries, necessitated further investigations of AD and PD in this population for a clearer understanding of their characteristics . Here, we explored the potential of blood-based markers to differentiate AD and PD from healthy controls via measuring the serum level of a panel of inflammatory cytokines as well as α-Syn in a small pilot cohort. The current data is the first to provide evidence in an Egyptian cohort that serum level of α-synuclein can be a specific marker for distinguishing PD patients from healthy individuals but not AD patients. Both AD and PD exhibited shared neuroinflammatory profiles with elevated IL-6 and decreased IL-10, while trends toward increased IL-1β and TNF-α were observed in AD.
