Improvement of brain function by wasabi component “hexaraphane”

Hexaraphane (6-methylsulfinylhexyl isothiocyanate; 6-MSITC) is an isothiocyanate present in the rhizomes and roots of Wasabi (Eutrema japonicum (Miq.) Kiudz.). Here we present the results of two clinical trials conducted on healthy subjects and patients with chronic fatigue syndrome using an extract powder "Wasabi sulfinyl^TM (WS)" containing 0.8% hexaraphane. In randomized controlled trial conducted on healthy middle-aged and elderly subjects improved memory for three months intaking of 100mg WS. In a clinical trial of fifteen patients with myalgic encephalomyelitis /chronic fatigue syndrome (ME/CFS) treatment with 1.2g WS for three months improved brain fog and other symptoms.